Licab XR 400 is an extended-release formulation of lithium carbonate, delivering 400mg per tablet for sustained mood stabilization. It is primarily indicated for bipolar disorder management, offering reliable control over manic, hypomanic, and depressive episodes through steady serum lithium levels.

• Sleep & Mental Health > Bipolar Disorder
  Licab XR 400 is widely used for acute mania, bipolar depression, and long-term relapse prevention. It helps stabilize mood swings and reduces hospitalization rates by maintaining therapeutic lithium concentrations.

• Sleep & Mental Health > Depression, Anxiety, PTSD
  Used adjunctively with antidepressants, Licab XR 400 supports emotional regulation in patients with resistant depression, chronic anxiety, or PTSD. It enhances response rates when monotherapy proves inadequate.

• Sleep & Mental Health > Suicidal Ideation Prevention
  Extensive studies confirm lithium’s protective role against suicidal behavior. Licab XR 400 is often part of care strategies for individuals at elevated suicide risk, with demonstrated reductions in ideation and attempts.

Lithium carbonate influences neuronal signal transduction by inhibiting inositol monophosphatase and affecting second messenger systems. This modulation reduces the hyperactivity of neurotransmitters such as dopamine and glutamate, helping stabilize mood and prevent neurochemical imbalances.

• Adults & Children >30kg
  → Tablets: 300 mg TID or 400 mg BID (XR form)
  → Oral Solution: 8 mEq (5 mL) TID
  → Monitor serum lithium after 3 days (12 hours post-dose)

• Children 20–30kg
  → Tablets: 300 mg BID
  → Oral Solution: 8 mEq (5 mL) BID

• Acute Mania / Mixed States
  → Target lithium level: 0.8–1.2 mEq/L

• Maintenance Therapy
  → Target lithium level: 0.8–1.0 mEq/L

• Pre-Treatment Requirements
  → Assess renal & thyroid function, electrolytes, vitals, medication interactions, and pregnancy status

• Mild to Moderate Renal Impairment
  → Initiate with reduced doses
  → Titrate slowly with frequent laboratory monitoring

• Severe Renal Impairment
  → Avoid lithium use

• Store in a dry, cool environment below 25°C, away from heat and direct sunlight.
• Keep the container tightly sealed.
• Do not freeze the oral solution.
• Check the expiration date regularly.
• Store out of reach of children.

• Common side effects
  → Hand tremors
  → Nausea
  → Polyuria (frequent urination)
  → Cognitive dulling
  → Hypothyroidism
  → Renal function changes

• Rare but serious side effects
  → Severe lithium toxicity with confusion
  → Unsteady gait (ataxia)
  → Vomiting
  → Cardiac irregularities

• Precautions / Monitoring
  → Regular monitoring of serum lithium levels, renal function, and thyroid function is essential
  → Seek immediate medical attention if symptoms of toxicity appear (confusion, fainting, chest irregularities)