Lithosun XR 400 is an extended-release psychiatric medication containing 400mg of lithium carbonate per tablet. It is formulated for sustained delivery, offering stable plasma concentrations over time. This helps ensure continuous mood stabilization and is particularly effective in preventing relapses in patients with chronic bipolar spectrum disorders.

- Sleep & Mental Health > Bipolar Disorder Lithosun XR 400 is commonly used to treat both the manic and depressive phases of bipolar disorder. It reduces the frequency, duration, and intensity of mood episodes and is one of the most evidence-supported agents for long-term maintenance therapy in bipolar I disorder. > Depression, Anxiety, PTSD Lithium carbonate may serve as an adjunct to antidepressants for treatment-resistant depression or anxiety-related disorders such as PTSD. In such cases, it can enhance emotional regulation and stabilize mood, especially in patients with fluctuating affective symptoms. > Suicidal Ideation Prevention Multiple clinical trials have demonstrated that lithium significantly lowers the risk of suicide attempts and completions. Lithosun XR 400 is recommended for high-risk psychiatric patients with a history of suicidal ideation or behavior.

Lithium carbonate exerts its effect through modulation of neurotransmitter systems and second messenger pathways such as inositol monophosphate inhibition. It also alters sodium transport in nerve and muscle cells and enhances neuroprotective mechanisms, contributing to its stabilizing effects on mood and behavior.

Adult & Pediatric Dosing Summary > Adults & Children over 30 kg - Tablets: 300 mg TID or 400 mg BID (XR form) - Oral Solution: 8 mEq (5 mL) TID - Monitor serum levels 12 hours after last dose on day 3 > Children 20–30 kg - Tablets: 300 mg BID - Oral Solution: 8 mEq (5 mL) BID > Acute Mania or Mixed Episodes - Titrate to serum concentration: 0.8–1.2 mEq/L > Maintenance Therapy - Titrate to maintain levels: 0.8–1.0 mEq/L > Pre-treatment Evaluation - Renal function, electrolytes, thyroid hormones, pregnancy status, concurrent medications > Mild to Moderate Renal Impairment - Initiate with lower doses, titrate slowly under close monitoring > Severe Renal Impairment - Lithium therapy is contraindicated; avoid use entirely

Store at temperatures below 25°C in a dry, well-sealed container. Avoid direct sunlight, moisture, or excessive heat. Keep out of reach of children and ensure regular checking of the expiration date to maintain potency and safety.

Common side effects include increased thirst, frequent urination, hand tremors, mild nausea, and cognitive dullness. With long-term use, patients may develop thyroid abnormalities or renal function decline. Signs of lithium toxicity—such as confusion, vomiting, ataxia, or seizures—require urgent medical attention. Routine monitoring is essential for safe use.