Naltrex On 50 is a generic naltrexone 50mg oral tablet developed to support recovery in individuals with alcohol or opioid dependence. As an opioid antagonist, naltrexone binds to opioid receptors in the brain without activating them, effectively blocking the euphoric and sedative effects associated with alcohol and opioids. This receptor blockade significantly reduces cravings and the risk of relapse, particularly in patients who are committed to long-term abstinence and are actively participating in structured treatment programs. In alcohol use disorder, Naltrex On 50 helps patients disengage from the psychological reward cycle of drinking. In opioid dependence, it provides a non-addictive alternative that prevents recurrence without the sedation or dependency issues associated with agonist therapies like methadone or buprenorphine. Additionally, low-dose naltrexone (LDN) is being studied for its emerging role in treating depression, autoimmune disorders, and obsessive-compulsive behaviors by modulating neuroinflammation and endorphin pathways.

- Sleep & Mental Health > Alcoholism Used to reduce cravings and prevent relapse in individuals with alcohol dependence by blocking opioid receptors involved in alcohol-induced reward and reinforcement. - Sleep & Mental Health > Depression (Low-Dose Naltrexone) Experimental evidence supports the use of low-dose naltrexone (typically 1–5 mg) to modulate immune and neurological responses involved in chronic depression and inflammation-related mood disorders. - Sleep & Mental Health > Obsessive-Compulsive Disorder (OCD) In select cases, used off-label to reduce obsessive thoughts and compulsive behaviors as a secondary mechanism when standard treatments are insufficient.

Naltrexone is a long-acting, non-addictive opioid receptor antagonist that exerts its therapeutic effect by preventing the activation of the mu, kappa, and delta opioid receptors. This blockade disrupts the cycle of reward reinforcement typically induced by alcohol or opioids, reducing the desire to use. Unlike partial agonists like buprenorphine, naltrexone has no abuse potential, making it suitable for patients who have already detoxified and seek to maintain sobriety. It also shows promise in off-label use for regulating mood, compulsivity, and immune function due to its downstream effects on neurotransmitter systems and microglial activity.

Usual Adult Dose for Alcohol Dependence (Oral): → 50 mg orally once daily Duration: Generally 12 weeks, but may be continued longer based on clinical judgment and relapse risk. Usual Adult Dose for Alcohol Dependence (Intramuscular): → 380 mg intramuscularly once every 4 weeks Usual Adult Dose for Opiate Dependence (Oral): → Initial dose: 25 mg orally once daily → Maintenance dose: 50 mg orally once daily (if no withdrawal occurs at initial dose) Usual Adult Dose for Opiate Dependence (Intramuscular): → 380 mg intramuscularly once every 4 weeks Comments: - Patients must be opioid-free for at least 7–14 days before initiating naltrexone to avoid precipitated withdrawal. - Transitioning from methadone or buprenorphine should be done cautiously with symptomatic management using non-opioid medications. - Success of therapy is heavily dependent on adherence and integration into a broader psychosocial treatment plan.

Store below 25°C in a cool, dry environment. Protect from excessive humidity, light, and heat. Keep tightly closed in original packaging, out of reach of children.

Common side effects: nausea, fatigue, headache, insomnia, dizziness Less common: joint pain, decreased appetite, increased anxiety, delayed menstruation Serious but rare: liver toxicity, severe allergic reactions, depressive symptoms, suicidal ideation Regular liver function tests and psychiatric monitoring are recommended during prolonged use.