Naltrust 50 is a generic oral formulation containing 50mg of naltrexone, a long-acting opioid antagonist primarily prescribed for the treatment of alcohol and opioid dependence. It helps individuals by blocking the euphoric and sedative effects of these substances, reducing cravings and discouraging relapse. This medication is most effective when integrated into a comprehensive treatment program that includes behavioral therapy, psychological support, and strict adherence. Low-dose applications (LDN) have also shown potential in managing mood disorders and chronic pain by regulating neuroinflammatory responses.

- Sleep & Mental Health > Alcoholism Used to reduce cravings and alcohol intake by blocking the reward pathways triggered by alcohol consumption, supporting sustained abstinence. - Sleep & Mental Health > Depression (Low-Dose Naltrexone) Explored as an adjunct therapy for improving mood and alleviating symptoms of depression through modulation of endorphin release and immune activity. - Sleep & Mental Health > Obsessive-Compulsive Disorder (OCD) Used experimentally to help manage compulsive behavior and reduce urges, particularly in treatment-resistant OCD cases.

Naltrexone works by competitively binding to opioid receptors in the brain, effectively blocking both endogenous and exogenous opioids. In alcohol dependence, it reduces dopamine release in the nucleus accumbens, diminishing the reinforcing effects of alcohol. This mechanism supports abstinence while presenting no addictive properties, and its once-daily dosing provides therapeutic convenience and compliance.

Usual Adult Dose for Alcohol Dependence (Oral): → 50 mg orally once a day Duration: Typically 12 weeks, extendable depending on clinical response Usual Adult Dose for Alcohol Dependence (Intramuscular): → 380 mg IM once every 4 weeks Usual Adult Dose for Opiate Dependence (Oral): → Initial: 25 mg once daily → Maintenance: 50 mg once daily (if no withdrawal symptoms) Usual Adult Dose for Opiate Dependence (Intramuscular): → 380 mg IM once every 4 weeks Comments: - Do not start until the patient has been opioid-free for 7–14 days. - May precipitate withdrawal if administered prematurely. - Treatment success improves with adherence, education, and supportive therapy.

Store at room temperature below 25°C in a dry place. Avoid humidity, direct sunlight, and extreme heat. Keep container tightly closed and out of children’s reach.

Common: nausea, fatigue, headache, insomnia, anxiety Less common: abdominal pain, decreased appetite, joint pain Rare/Serious: liver toxicity, depression, allergic reactions Liver function monitoring is recommended during prolonged use. Discontinue and consult a physician if mood disturbances or jaundice occur.