Pari CR 12.5 is an advanced controlled-release tablet containing paroxetine, a selective serotonin reuptake inhibitor (SSRI) used to treat a broad range of psychiatric conditions. Its prolonged-release mechanism ensures steady blood concentration, enhancing tolerability and minimizing abrupt mood shifts. It is widely prescribed for depression, anxiety, OCD, PTSD, panic attacks, and PMDD.

- Sleep & Mental Health > Depression, Anxiety, PTSD Pari CR 12.5 is frequently used in managing major depressive disorder (MDD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). Its clinical effect lies in restoring emotional equilibrium, reducing anxious anticipation, and calming intrusive thoughts. > Obsessive-Compulsive Disorder (OCD) Paroxetine, a trusted SSRI, is approved for alleviating the symptoms of OCD by targeting repetitive thought patterns and ritualistic behaviors, offering relief from the cycle of obsession and compulsion. > Panic Disorder This medication is also effective in mitigating the severity and recurrence of panic attacks, improving daily function and long-term anxiety control. The CR formulation allows for smoother symptom relief with reduced side effect peaks.

Pari CR 12.5 enhances serotonergic activity in the brain by inhibiting the reuptake of serotonin, a key neurotransmitter responsible for mood regulation. This leads to improved emotional balance, fewer anxiety episodes, and reduced obsessive tendencies, with sustained therapeutic effects.

Adult Dosing 1. Depression & MDD - CR: Start 25 mg/day → Maintenance 25–62.5 mg/day → Max 62.5 mg - Increase weekly by 12.5 mg 2. GAD & PTSD - IR: Start 20 mg/day → Maintenance 20–50 mg/day → Max 50 mg - Weekly increase: 10 mg 3. Panic Disorder (PD) - CR: Start 12.5 mg/day → Maintenance 12.5–75 mg/day → Max 75 mg - Weekly increase: 12.5 mg 4. Social Anxiety Disorder (SAD) - CR: Start 12.5 mg/day → Maintenance 12.5–37.5 mg/day → Max 37.5 mg - Weekly increase: 12.5 mg 5. PMDD (CR Only) - Continuous: 12.5–25 mg/day - Cyclic: 12.5 mg/day from day -14 to day 1 of menstruation 6. OCD - IR: Start 20 mg/day → Maintenance 20–60 mg/day → Max 60 mg - Weekly increase: 10 mg 7. Menopausal Symptoms - Dose: 7.5 mg/day (non-psychiatric) Geriatric Dosing 1. Depression & MDD - CR: Start 12.5 mg/day → Maintenance 12.5–50 mg/day → Max 50 mg 2. GAD, PTSD, OCD, SAD - IR: Start 10 mg/day → Maintenance 10–40 mg/day → Max 40 mg 3. Panic Disorder - CR: Start 12.5 mg/day → Maintenance 12.5–50 mg/day → Max 50 mg

Store at temperatures below 30°C in a cool, dry place away from moisture and direct sunlight. Keep it in its original packaging and out of the reach of children and pets. Do not refrigerate or freeze.

Possible side effects include drowsiness, dry mouth, nausea, insomnia, and sweating. Sexual dysfunction and weight changes may occur. In rare cases, patients may experience serotonin syndrome, suicidal ideation, or withdrawal symptoms. Tapering should be supervised by a healthcare provider.