Pexep CR 12.5 is an advanced controlled-release tablet formulation of paroxetine, a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for a wide range of mental health disorders. It provides steady serotonin modulation throughout the day, helping to stabilize emotional fluctuations and reduce anxiety surges. Known for its balanced efficacy and tolerability, it is used in clinical practice to manage chronic depression, panic attacks, OCD, and PTSD.

- Sleep & Mental Health > Depression, Anxiety, PTSD Pexep CR 12.5 helps manage the core symptoms of major depressive disorder (MDD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). It reduces mood instability and intrusive thoughts while promoting emotional resilience. > Obsessive-Compulsive Disorder (OCD) Paroxetine’s efficacy in OCD treatment is backed by FDA approval. Pexep CR 12.5 is particularly effective in reducing compulsive behavior and intrusive obsessions by modulating the serotonin pathways. > Panic Disorder This CR tablet is also highly recommended for panic disorder, as it lessens the frequency of panic attacks and improves long-term recovery. The gradual release format ensures smoother onset and fewer peaks in side effects.

Pexep CR 12.5 acts by selectively inhibiting the reuptake of serotonin in the brain, enhancing its concentration in the synaptic cleft. This regulation improves communication between nerve cells, supports mood elevation, and helps restore neurochemical balance in patients with anxiety and depressive disorders.

Adult Dosing 1. Depression & MDD: CR: Start 25 mg/day → Maintenance 25–62.5 mg/day → Max 62.5 mg 2. GAD & PTSD: IR: Start 20 mg/day → Maintenance 20–50 mg/day → Max 50 mg 3. Panic Disorder: CR: Start 12.5 mg/day → Maintenance 12.5–75 mg/day → Max 75 mg 4. SAD: CR: Start 12.5 mg/day → Maintenance 12.5–37.5 mg/day → Max 37.5 mg 5. PMDD: CR: Continuous 12.5–25 mg/day or Cyclic 12.5 mg/day (14 days pre-menses) 6. OCD: IR: Start 20 mg/day → Maintenance 20–60 mg/day → Max 60 mg 7. Menopausal Symptoms: Mesylate capsule: 7.5 mg/day Geriatric Dosing 1. Depression & MDD: CR: Start 12.5 mg/day → Maintenance 12.5–50 mg/day → Max 50 mg 2. GAD, PTSD, OCD, SAD: IR: Start 10 mg/day → Maintenance 10–40 mg/day → Max 40 mg 3. Panic Disorder: CR: Start 12.5 mg/day → Maintenance 12.5–50 mg/day → Max 50 mg

Store in a cool, dry place below 30°C, protected from light and moisture. Keep in original packaging and out of children's reach. Do not refrigerate.

Possible side effects include headache, dizziness, drowsiness, nausea, constipation, dry mouth, sexual dysfunction, and weight gain. Rare but serious effects include serotonin syndrome, withdrawal symptoms, and suicidal thoughts in younger patients. Tapering is essential for discontinuation.