Pexep CR 25 is a generic controlled-release paroxetine tablet, part of the SSRI class of antidepressants. It is designed to maintain consistent serotonin levels in the brain, which helps alleviate symptoms of depression, anxiety, panic disorders, and related psychiatric conditions. The CR formulation allows for smoother drug delivery, improving patient adherence and minimizing side effects commonly seen with immediate-release forms.

- Sleep & Mental Health > Depression, Anxiety, PTSD Pexep CR 25 effectively treats major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and post-traumatic stress disorder (PTSD), providing emotional stability and stress regulation. > Obsessive-Compulsive Disorder (OCD) It is an FDA-approved SSRI for OCD, reducing repetitive obsessions and compulsions by balancing serotonin activity. > Panic Disorder Pexep CR 25 reduces the frequency and intensity of panic attacks and helps prevent recurrence in long-term management.

Paroxetine selectively inhibits serotonin reuptake transporters, increasing serotonin concentration in synapses. This rebalancing of neurotransmitters underlies its efficacy in mood regulation, anxiety reduction, and overall mental health improvement.

Adult Dosing - Depression & Major Depressive Disorder (MDD): IR: Start 20 mg daily; Maintenance 20–50 mg; Max 50 mg CR: Start 25 mg daily; Maintenance 25–62.5 mg; Max 62.5 mg Dose increments of 10 mg (IR) or 12.5 mg (CR) weekly. Typical treatment duration extends several months, with demonstrated benefits up to 1 year. - Social Anxiety Disorder (SAD): IR: Start 20 mg daily; Maintenance 20–60 mg; Max 60 mg CR: Start 12.5 mg daily; Maintenance 12.5–37.5 mg; Max 37.5 mg Treatment may last up to 12 weeks, with weekly dosage increases. - Panic Disorder (PD): IR: Start 10 mg daily; Maintenance 10–40 mg; Max 60 mg CR: Start 12.5 mg daily; Maintenance 12.5–75 mg; Max 75 mg Duration of treatment typically up to 12 weeks with weekly dose titration. - Premenstrual Dysphoric Disorder (PMDD): CR formulation only, dosed 12.5–25 mg daily, either continuously or cyclically (starting 14 days before menstruation). Treatment recommended for a minimum of 3 cycles with weekly dose adjustments as needed. - Obsessive Compulsive Disorder (OCD): IR: Start 20 mg daily; Maintenance 20–60 mg; Max 60 mg Long-term treatment required; weekly dose increases of 10 mg. - Post-Traumatic Stress Disorder (PTSD) & Generalized Anxiety Disorder (GAD): IR: Start 20 mg daily; Maintenance 20–50 mg; Max 50 mg Treatment course typically 12 weeks with weekly dose escalation. - Postmenopausal Symptoms: Mesylate capsules at 7.5 mg daily, used for vasomotor symptom relief only. Geriatric Dosing: - Initiate at reduced doses (~10 mg daily) with maintenance doses up to 40 mg for conditions including OCD, PTSD, SAD, GAD, PD, and depression. - Dose increases should be gradual and monitored carefully due to increased sensitivity in elderly patients. - Avoid use for mild, short-term anxiety related to everyday stressors.

Store Pexep CR 25 tablets in a tightly closed container in a cool, dry place away from direct sunlight and moisture. Protect from heat and humidity to maintain drug potency. Keep out of reach of children and pets to avoid accidental ingestion.

Common side effects include nausea, dizziness, headache, fatigue, insomnia, dry mouth, sweating, and sexual dysfunction. Serious adverse effects may include serotonin syndrome, bleeding risks, and withdrawal symptoms upon sudden discontinuation. Monitor patients closely and adjust dosage or discontinue therapy as clinically indicated.