Agoprex 25 is a generic formulation of agomelatine 25mg, a novel antidepressant with dual action as a melatonergic agonist (MT1 and MT2 receptors) and serotonin 5-HT2C receptor antagonist. Unlike conventional antidepressants such as SSRIs or SNRIs, agomelatine enhances circadian rhythm regulation while improving mood, making it particularly effective in major depressive disorder (MDD) with comorbid sleep disturbances or anxiety. Its unique mechanism not only improves emotional stability but also helps restore natural sleep patterns, a key benefit for patients suffering from insomnia-linked depression.

- Sleep & Mental Health > Depression, Anxiety, PTSD Agoprex 25 is indicated for the treatment of major depressive episodes in adults, including cases with associated anxiety or post-traumatic stress disorder. It is especially suitable for patients whose depressive symptoms are accompanied by disrupted sleep-wake cycles, as it helps reset circadian rhythms and reduce nocturnal arousal. > Insomnia/Sleep Aid Unlike traditional hypnotics or benzodiazepines, agomelatine promotes sleep by mimicking the action of endogenous melatonin and helps establish a more physiologically natural sleep pattern. It supports deep, uninterrupted sleep and next-day alertness without the risk of dependency.

Agomelatine binds to melatonin receptors MT1 and MT2 to reinforce circadian rhythm synchronization, thereby improving sleep quality and onset latency. Simultaneously, it antagonizes 5-HT2C receptors, leading to an increase in dopamine and norepinephrine levels in the frontal cortex—neurotransmitters vital for motivation and emotional regulation. This dual action helps alleviate core depressive symptoms, enhances mood stability, and supports natural sleep restoration.

Usual Adult Dose for Major Depressive Disorder: - Recommended dose: 25 mg orally once daily, taken at bedtime - If no improvement is seen after 2 weeks, the dose may be increased to 50 mg once daily at bedtime - Duration of treatment: At least 6 months after symptom resolution to prevent relapse Comments: - Take the tablet at bedtime to align with the body’s circadian rhythm - Can be taken with or without food - Regular liver function monitoring is required, especially during the first 3 months - Dose should not exceed 50 mg/day - If discontinued, tapering is not typically required due to its receptor profile, but clinical judgment is advised Use: Treatment of major depressive disorder (MDD) in adults, especially when sleep disturbances are prominent.

Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the packaging.

- Common: Headache, dizziness, nausea, fatigue, increased sweating, insomnia or vivid dreams - Less Common: Weight gain, back pain, liver enzyme elevation - Rare but Serious: Hepatotoxicity (monitor ALT/AST), suicidal ideation (especially in young adults), severe allergic reactions - Note: Unlike SSRIs, it does not cause sexual dysfunction or discontinuation syndrome in most cases