Noveltin 25 contains agomelatine 25mg, a unique antidepressant that combines melatonergic agonism and serotonin antagonism. It regulates circadian rhythms while improving mood and reducing symptoms of depression and anxiety. As a dual-acting agent, it offers a new approach to treating mood disorders, especially in patients who struggle with sleep issues in addition to emotional instability. Noveltin 25 is considered a gentler option for long-term use, with a reduced risk of common side effects such as sexual dysfunction or weight gain often seen with SSRIs and SNRIs.

- Sleep & Mental Health > Depression, Anxiety, PTSD Noveltin 25 is indicated for major depressive disorder (MDD), particularly when associated with insomnia, anxiety, or PTSD. It supports emotional recovery by increasing dopamine and norepinephrine levels in the frontal cortex, helping to restore positive mood and improve resilience against stress-related symptoms. > Insomnia / Sleeping Aids By mimicking the effects of melatonin at MT1 and MT2 receptors, Noveltin 25 helps realign disrupted sleep-wake cycles. It improves the quality of sleep without sedative dependence, making it ideal for depression patients suffering from delayed sleep onset or frequent nighttime awakenings.

Agomelatine works by binding to MT1 and MT2 receptors, reinforcing natural melatonin activity, and blocking 5-HT2C receptors to increase dopamine and norepinephrine release in the prefrontal cortex. This action supports both neurochemical balance and circadian rhythm regulation, making it highly effective in treating mood disorders with associated sleep dysfunction. It improves motivation, concentration, and emotional stability with minimal cognitive dulling.

Usual Adult Dose for Major Depressive Disorder: - Starting dose: 25 mg orally once daily at bedtime - If no clinical improvement is observed after 2 weeks, the dose may be increased to 50 mg once daily - Maximum dose: 50 mg/day - Duration: At least 6 months of continued treatment after symptom remission is recommended to prevent relapse Comments: - Administer at bedtime to align with the body’s circadian system - No tapering is required when stopping the drug - Liver function tests are recommended before initiation and periodically thereafter - It may be taken with or without meals Use: Treatment of major depressive episodes in adults, particularly when insomnia is a core symptom

Store below 25°C in a dry, cool environment. Protect from light and moisture. Keep out of reach of children and do not use past the expiration date printed on the packaging.

- Common: Headache, dizziness, gastrointestinal discomfort, fatigue, insomnia, abnormal dreams - Less Common: Anxiety, mild weight changes, increased liver enzymes - Rare: Liver injury, suicidal ideation (especially in younger patients), skin rash or hypersensitivity reactions Note: Unlike SSRIs, Noveltin 25 typically does not impair sexual function or cause significant withdrawal symptoms upon discontinuation.