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(60)
| Generic For | FEMARA |
|---|---|
| Active Ingredient | LETROZOLE |
| Strength | 2.5MG |
| Manufacturer | CIPLA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 2 BOXES - 100 TABLETS | $ 0.51 | $ 50.90 |
$ 43.27
Apply ZARVY26 (-15%)
You save $ 7.64
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| 3 BOXES - 150 TABLETS | $ 0.50 |
2% $ 76.35
$ 75.20
|
$ 63.92
Apply ZARVY26 (-15%)
You save $ 11.28
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| ★ Best Value 6 BOXES - 300 TABLETS | $ 0.48 |
6% $ 152.70
$ 144.10
|
$ 122.49
Apply ZARVY26 (-15%)
You save $ 21.62
|
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Fempro 2.5 is an oral non-steroidal aromatase inhibitor containing letrozole 2.5mg, designed to reduce systemic estrogen production by blocking the aromatase enzyme. As estrogen fuels the growth of hormone receptor-positive (HR+) breast cancer, letrozole serves as a cornerstone of endocrine therapy in postmenopausal women. It is indicated for both adjuvant and metastatic settings and can be used either as monotherapy or in combination with targeted agents such as CDK4/6 inhibitors. Letrozole's long-term benefits in recurrence prevention have made it a standard of care in hormone-sensitive breast cancer. Additionally, it has gained attention in reproductive medicine for its role in inducing ovulation among women with polycystic ovary syndrome (PCOS) and other ovulatory disorders.
- AntiCancer Drugs > HR+ Breast Cancer in Postmenopausal Women Approved for adjuvant, neoadjuvant, and metastatic endocrine therapy in postmenopausal women with hormone receptor-positive breast cancer. Letrozole acts by suppressing estrogen biosynthesis, thereby inhibiting tumor growth and recurrence. > Advanced or Metastatic Breast Cancer Used in combination with fulvestrant or CDK4/6 inhibitors such as ribociclib or palbociclib as initial endocrine-based therapy. Offers superior progression-free survival in advanced HR+/HER2- breast cancer. - FEMTECH > Ovulation Induction for Infertility Commonly prescribed off-label for ovulation induction in women with anovulation, particularly those with PCOS. Letrozole improves follicular development, increases ovulation rates, and is associated with favorable pregnancy outcomes in fertility protocols.
Letrozole selectively inhibits the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. In postmenopausal women, this is the primary source of estrogen. By drastically lowering circulating estrogen levels, letrozole deprives hormone-dependent breast cancer cells of their growth signal. The drug has minimal effect on adrenal or ovarian steroidogenesis, making it safer for long-term use. It also demonstrates a favorable bone safety profile when monitored appropriately. In fertility treatment, its estrogen-lowering action indirectly stimulates the hypothalamic-pituitary-ovarian axis, promoting endogenous FSH release and ovulation.
Standard Dose in Breast Cancer: → Letrozole: 2.5 mg orally once daily → Take continuously throughout a 28-day cycle without break → Duration varies: from 5 years to 10 years depending on risk assessment and recurrence history → May be initiated after surgery (adjuvant) or prior to surgery (neoadjuvant) In Combination Therapy: → With Ribociclib: 600 mg ribociclib daily for 21 days, followed by 7 days off (28-day cycle) → Letrozole is taken daily without interruption during the same cycle → Appropriate for pre-, peri-, and postmenopausal patients when combined with ovarian suppression Ovulation Induction (Off-label use): → Typically 2.5–5 mg orally daily for 5 days, starting on day 3 or 5 of menstrual cycle → Dosage and duration may vary based on ovulatory response and clinician guidance Administration Tips: → May be taken with or without food → If a dose is missed, Take as soon as remembered unless it’s close to the next dose. Do not double up. → Use of reliable contraception is recommended during therapy if pregnancy is not intended
Store at room temperature below 25°C. Protect from light and moisture. Do not remove tablets from blister pack until ready to use. Keep out of reach of children and dispose of expired medication safely.
Common: hot flashes, fatigue, joint pain, increased sweating, nausea Less Common: osteoporosis, elevated cholesterol, headache, insomnia Rare: severe bone density loss, liver enzyme elevation, cardiovascular events Consult a healthcare provider if symptoms such as persistent joint stiffness, chest pain, or yellowing of the skin occur.
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