Exchange & Returns Information
Review Details
(0)
| Generic For | MEGACE |
|---|---|
| Active Ingredient | MEGESTROL ACETATE |
| Strength | 40MG |
| Manufacturer | SAMARTH LIFE SCIENCES PVT LTD |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 2 BOXES - 60 TABLETS | $ 0.52 | $ 31.00 |
$ 26.35
Apply ZARVY26 (-15%)
You save $ 4.65
|
||
| 3 BOXES - 90 TABLETS | $ 0.71 | $ 64.00 |
$ 54.40
Apply ZARVY26 (-15%)
You save $ 9.60
|
||
| ★ Best Value 6 BOXES - 180 TABLETS | $ 0.61 | $ 110.00 |
$ 93.50
Apply ZARVY26 (-15%)
You save $ 16.50
|
Reference information will be available soon.
Endace 40 is an oral generic formulation of megestrol acetate 40mg, a synthetic progestin with strong anti-estrogenic properties. It is primarily indicated in hormone-sensitive cancers, including advanced breast cancer and endometrial cancer, where it works by inhibiting estrogen-driven tumor growth.
Beyond oncology, megestrol acetate is widely used in the management of cachexia and severe anorexia associated with cancer or HIV/AIDS. Its appetite-stimulating effect supports weight gain and improves nutritional status in debilitated patients.
Because of this dual action—tumor growth suppression and appetite stimulation—Endace 40 holds an important role as a palliative therapy across multiple oncological and wasting-related conditions.
AntiCancer Drugs > Hormone-Responsive Breast Cancer
Used for palliative management of metastatic or recurrent hormone-receptor-positive breast cancer in postmenopausal women. Often prescribed when patients show resistance to other anti-estrogen agents such as tamoxifen.
AntiCancer Drugs > Endometrial Cancer
Indicated for advanced or inoperable endometrial carcinoma, particularly in elderly patients unfit for surgery. Functions by suppressing estrogen-driven tumor growth.
AntiCancer Drugs > Cancer Cachexia & Anorexia
Employed to stimulate appetite and promote weight gain in cancer patients suffering from muscle wasting or poor oral intake. Helps mitigate the catabolic metabolic effects of malignancy.
AntiCancer Drugs > HIV/AIDS-Related Wasting Syndrome
Approved for the treatment of significant weight loss in HIV/AIDS patients. Enhances caloric intake and supports weight recovery in those with progressive wasting symptoms.
Megestrol acetate acts as a potent synthetic progestin, exerting its therapeutic effects through both hormonal modulation and metabolic regulation.
In hormone-responsive cancers, it functions as an anti-estrogenic agent, antagonizing estrogen receptors and suppressing estrogen-dependent tumor proliferation.
In cachexia and anorexia, it promotes appetite stimulation, supports positive energy balance, and facilitates weight gain in debilitated patients.
The drug is non-cytotoxic, generally well tolerated for long-term palliative use, and does not carry a risk of addiction, as it is not classified as a narcotic.
For Hormone-Responsive Breast Cancer (Palliative):
→ 40 mg orally 4 times daily
→ Minimum trial period: 2 months to evaluate efficacy
→ Not intended to replace curative modalities such as surgery or chemotherapy
For Endometrial Cancer (Palliative):
→ 40–320 mg/day orally in divided doses
→ Duration of trial: at least 2 months
→ Typically reserved for patients unsuitable for invasive treatment
For AIDS-related Anorexia / Cachexia:
→ Suspension 40 mg/mL: 800 mg once daily (20 mL)
→ Suspension 125 mg/mL: 625 mg once daily (5 mL)
→ Suspension ES 125 mg/mL: 625 mg once daily (1 mL)
Important Notes:
→ 40 mg/mL and 125 mg/mL are not interchangeable on a mg-to-mg basis
→ Shake suspension thoroughly before use
→ Evaluate for reversible causes of anorexia before initiating
→ Not for preventative use in weight loss
Administration:
→ May be taken with or without food
→ If a dose is missed, take as soon as remembered unless it is close to the next dose. Do not double up
Store at controlled room temperature, preferably below 25°C
Avoid exposure to direct sunlight, humidity, or high heat
Ensure cap is tightly sealed after each use
Keep out of reach of children
Common: weight gain, increased appetite, nausea, fluid retention, insomnia
Less common: thromboembolic events, hypertension, mood changes, adrenal suppression
Rare: hyperglycemia, deep vein thrombosis, Cushingoid features
Discontinue and consult a physician if serious side effects such as chest pain, persistent leg swelling, or sudden confusion occur.
No reviews yet. Be the first to review this product!
No combo deals available at the moment.
