Evadiol 2mg, Estradiol Valerate, Women’s Health, Hormone Replacement Therapy, Online Pharmacy
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Evadiol 2mg Tablet

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Generic For PROGYNOVA
Active Ingredient ESTRADIOL VALERATE
Strength 2MG
Manufacturer INTAS PHARMACEUTICALS
Estraheal 2 28 tablets blister pack estradiol hormone replacement therapy online pharmacy
Estraheal 2 28 tablets box with blister strips estradiol estrogen medicine online pharmacy
Estraheal 2 28 tablets branded box packaging estradiol hormone therapy online pharmacy
Estraheal 2 28 tablets blister pack estradiol hormone replacement therapy online pharmacy
Estraheal 2 28 tablets box with blister strips estradiol estrogen medicine online pharmacy
Estraheal 2 28 tablets branded box packaging estradiol hormone therapy online pharmacy
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Product Description

Evadiol 2mg Tablet is an oral hormone therapy containing Estradiol Valerate, a synthetic estrogen ester converted into active estradiol in the body. With enhanced bioavailability and prolonged duration of action, this formulation is primarily used in managing moderate to severe estrogen deficiency states. It is particularly effective in treating postmenopausal symptoms, maintaining bone health, and addressing hypoestrogenic conditions. Additionally, it plays a role in hormone-responsive cancers and serves as a key component in certain off-label protocols, including gender-affirming hormone therapy.

Indications & Uses

  • HORMONES & MENOPAUSAL SYMPTOMS > Menopausal Hormone Therapy Used to alleviate menopausal symptoms such as hot flashes, night sweats, and sleep disturbances.
  • FEMTECH > Menstrual Control Helps in managing irregular or absent menstruation due to ovarian dysfunction or surgical menopause.
  • FEMTECH > Vaginal & Urethral Atrophy Improves urogenital atrophy, reducing symptoms like dryness, itching, and recurrent infections.
  • LIFESTYLE-RELATED DISEASES > Osteoporosis Prescribed for the prevention of bone mineral density loss in postmenopausal individuals.
  • DISEASES/SYMPTOMS > Hypoestrogenism Indicated in women with ovarian insufficiency, premature menopause, or functional amenorrhea.
  • AntiCancer Drugs > Prostate Cancer Used in androgen deprivation therapy to suppress testosterone in hormone-sensitive malignancies.
  • AntiCancer Drugs > Breast Cancer Applied in palliative treatment for select postmenopausal breast cancer cases.
  • AntiCancer Drugs > Others (for off-label hormonal modulation) Supports estrogenic balance in transgender care and rare endocrine disorders.

Benefits & Effectiveness

Estradiol Valerate, upon enzymatic hydrolysis, delivers systemic estradiol, binding to estrogen receptors across various target tissues. It modulates gene transcription, restores vaginal epithelium, stabilizes thermoregulation in the hypothalamus, and maintains cardiovascular and skeletal integrity. In oncological settings, it inhibits androgen-driven tumor growth and provides endocrine regulation, offering therapeutic benefits in select cancers.

Directions for Use

  • Postmenopausal Symptoms - Oral: 1–2 mg daily in cyclic regimen (3 weeks on, 1 week off), Transdermal Patches: Twice-weekly (Vivelle-Dot) start 0.0375–0.05 mg/day; maintain 0.025–0.1 mg/day, Once-weekly (Climara) begin 0.025 mg/day; titrate to 0.1 mg/day, Gel (Divigel) 0.25–1.25 mg/day applied to thigh, Metered Pump (Estrogel) 0.52–0.75 mg/day to upper arm, Spray (Evamist) 1.53 mg/spray, up to 3 sprays/day to forearm, Vaginal Ring (Femring) replace every 90 days (0.05–0.1 mg/day), IM Injection: Cypionate 1–5 mg every 3–4 weeks, Valerate 10–20 mg every 4 weeks
  • Atrophic Urethritis / Vaginitis - Prefer topical or vaginal estrogens for local symptoms, Systemic oral use if broader symptoms coexist
  • Hypoestrogenism / Ovarian Insufficiency - Oral: 1–2 mg/day, Transdermal patches and injections as alternative routes
  • Primary Ovarian Failure - Same regimens as hypoestrogenism, often long-term maintenance
  • Osteoporosis Prevention - Oral: minimum 0.5 mg/day; dose individualized, Patches: Twice-weekly 0.025 mg/day, Once-weekly (Climara) 0.025 mg/day, Menostar (low dose) 0.014 mg/day, Consider non-hormonal alternatives first if risk profile contraindicates estrogen
  • Breast Cancer (Palliative Use) - Oral: 10 mg three times daily for ≥3 months
  • Prostate Cancer (Palliative Use) - Oral: 1–2 mg three times daily, IM: Estradiol Valerate 30 mg or more every 1–2 weeks
  • General Notes - Always use lowest effective dose for shortest duration to minimize adverse risks, Add progestogen in women with uterus to prevent endometrial hyperplasia, Regularly monitor therapy response, liver function, and cardiovascular markers, Reassess continuation every 3–6 months depending on patient condition and goals

Storage

  • Store below 25°C, in a dry and shaded place.
  • Keep the tablets in their original blister until use to avoid moisture exposure. Do not freeze. Keep out of reach of children.

Possible Side Effects

Possible side effects include nausea, breast tension, headache, and bloating. Long-term use without progestogen may increase endometrial cancer risk. Other serious but rare effects include venous thromboembolism, hypertension, liver dysfunction, and gallbladder disease. Discontinue immediately if symptoms like sudden vision loss or chest pain occur.

FAQs

Evadiol 2mg contains estradiol valerate, a long-acting ester that offers a sustained hormonal effect and high oral bioavailability.
Yes, under medical supervision, it is used in feminizing hormone regimens for transgender women.
Many users notice relief from menopausal symptoms within 2–4 weeks, but full benefits may take up to 3 months.
Continuous use is possible but cyclic regimens are often preferred unless otherwise advised by a physician.
Yes, Evadiol 2mg is used in men for palliative treatment of prostate cancer and in specific hormonal protocols.

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