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| Generic For | LUPRON |
|---|---|
| Active Ingredient | LEUPROLIDE ACETATE |
| Strength | 11.25MG |
| Manufacturer | SAMARTH LIFE SCIENCES PVT LTD |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 1 VIAL | $ 105.50 | $ 105.50 |
$ 89.68
Apply ZARVY26 (-15%)
You save $ 15.83
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| 2 BOXES - 2 VIALS | $ 106.10 | $ 212.20 |
$ 180.37
Apply ZARVY26 (-15%)
You save $ 31.83
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| ★ Best Value 3 BOXES - 3 VIALS | $ 109.40 | $ 328.20 |
$ 278.97
Apply ZARVY26 (-15%)
You save $ 49.23
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Reference information will be available soon.
Duplat Depot 11.25 is a 3-month depot injection containing leuprolide acetate 11.25mg, a gonadotropin-releasing hormone (GnRH) agonist used in multiple hormone-responsive conditions. By providing continuous GnRH receptor stimulation, it induces downregulation of the pituitary–gonadal axis, leading to suppression of testosterone and estrogen production.
This mechanism results in a reversible chemical castration effect, making it an important therapy in the management of:
Advanced prostate cancer
Endometriosis
Uterine fibroids
Central precocious puberty
The 11.25mg long-acting formulation enables quarterly dosing, offering both treatment convenience and consistent hormonal suppression for long-term disease control.
AntiCancer Drugs > Prostate Cancer
Indicated for palliative treatment of advanced, recurrent, or metastatic prostate cancer. It lowers circulating testosterone levels to castrate range, thereby slowing tumor progression and alleviating associated symptoms. The 11.25mg depot formulation ensures reliable hormonal suppression for a 3-month duration.
Hormones & Menopausal Symptoms > Endometriosis
Used to induce a temporary menopausal state and reduce ectopic endometrial tissue activity. Treatment typically lasts up to 6 months, with injections administered every 3 months to relieve pelvic pain, dysmenorrhea, and menstrual irregularities.
Hormones & Menopausal Symptoms > Uterine Fibroid
Employed as a preoperative intervention to reduce fibroid volume and control abnormal bleeding. By suppressing estrogen-dependent fibroid growth, it can also improve hemoglobin levels prior to surgery.
Hormones & Menopausal Symptoms > Precocious Puberty
Indicated for children with central precocious puberty to delay early sexual maturation. Weight-adjusted regimens are used to achieve adequate hormone suppression, while the 3-month depot formulation allows for long-term maintenance with fewer injections.
Leuprolide acetate works through continuous stimulation of pituitary GnRH receptors, which initially causes a surge in LH and FSH, but is followed by receptor desensitization and subsequent hormonal suppression.
In men, this leads to a marked reduction in testosterone production, effectively mimicking the effects of orchiectomy.
In women and children, it lowers estrogen levels, thereby suppressing premature or pathological hormonal activity.
The depot injection provides a sustained release, ensuring consistent efficacy and reducing the frequency of dosing. While it is not curative, it plays a central role in the long-term control of hormone-dependent diseases.
Prostate Cancer (Adults):
→ 7.5 mg IM every 4 weeks
→ 22.5 mg IM every 12 weeks
→ 30 mg IM every 16 weeks
→ 45 mg IM every 24 weeks
→ Duplat Depot 11.25: administered every 3 months
→ Subcutaneous alternatives: CAMCEVI 42 mg (q6mo), ELIGARD (7.5–45 mg)
Endometriosis (Adults):
→ 3.75 mg IM monthly or
→ 11.25 mg IM every 3 months (max duration: 12 months)
→ Often co-prescribed with norethindrone to mitigate bone loss
Uterine Fibroid (Adults):
→ 3.75 mg IM monthly (for up to 3 months) or
→ 11.25 mg IM once as preoperative management
Central Precocious Puberty (Children ≥1 year):
→ ≤25 kg: 7.5 mg IM monthly
→ 25–37.5 kg: 11.25 mg monthly
→ >37.5 kg: 15 mg IM monthly
→ 11.25 or 30 mg every 3 months
→ Subcutaneous: FENSOLVI 45 mg every 6 months (≥2 years)
Administration Notes:
→ Must be administered by a healthcare professional via deep intramuscular injection
→ Avoid missing scheduled dosing intervals
→ If a dose is missed, take it as soon as possible and continue the regular schedule. Do not double the next dose
→ Monitor hormone levels and disease progression regularly during long-term therapy
Store in the original packaging under refrigeration or at controlled room temperature (below 25°C), according to formulation instructions
Do not freeze
Protect from light and excessive moisture
Keep out of reach of children
Do not use if the solution appears discolored or contains particles
Common: injection site pain, hot flashes, decreased libido, fatigue, emotional lability
Less common: gynecomastia, edema, acne, bone density loss, headache
Rare: cardiovascular events, depression, pituitary apoplexy, allergic reactions
Patients should stop treatment and consult a physician if they experience chest tightness, severe mood changes, or unusual bleeding.
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