Rexigo 120, Relugolix, AntiCancer Drugs, Prostate Cancer, Online Pharmacy
AntiCancer Drugs HORMONES Menstrual Irreg./Dysmen. Uterine Fibroid Endometriosis Prostate Cancer

Rexigo 120

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Generic For ORGOVYX
Active Ingredient RELUGOLIX
Strength 120MG
Manufacturer ZYDUS CADILA
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Product Description

Rexigo 120 is an oral tablet formulation containing 120 mg of Relugolix, a non-peptide GnRH receptor antagonist indicated for the treatment of advanced prostate cancer. Unlike conventional GnRH agonists, Relugolix provides rapid testosterone suppression without the initial surge, ensuring immediate and sustained androgen reduction. Taken once daily, it is especially valued for its oral convenience, favorable cardiovascular safety profile, and proven efficacy in both metastatic and non-metastatic castration-sensitive as well as castration-resistant prostate cancer.

Indications & Uses

  • AntiCancer Drugs > Prostate Cancer
    Rexigo 120 is indicated for the treatment of adult men with advanced prostate cancer, including both non-metastatic and metastatic stages. It is especially useful in patients with castration-sensitive prostate cancer (CSPC) as well as those progressing to castration-resistant prostate cancer (CRPC). As an oral GnRH antagonist, Relugolix suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH), resulting in a rapid decrease in testosterone levels—key to controlling prostate cancer growth. It avoids the initial testosterone surge seen with GnRH agonists, minimizing flare symptoms such as bone pain or urinary obstruction.

Benefits & Effectiveness

  • Competitive binding to pituitary GnRH receptors inhibits LH and FSH release, lowering testicular testosterone production
  • Rapid testosterone decline without an initial surge, reaching castrate levels within days
  • Effective for managing hormone-sensitive prostate tumors and delaying progression in CRPC
  • Clinical trials show a lower incidence of cardiovascular events compared with injectable therapies

Directions for Use

• Dosage & Administration
Prostate Cancer (Adults): Loading Dose is 360 mg orally once on Day 1. Maintenance Dose is 120 mg orally once daily starting from Day 2. Tablets should be taken at the same time each day, with or without food. No need for combination with anti-androgens due to lack of testosterone surge. Do not crush or chew the tablet; swallow whole.

• Important Notes
Use in patients with advanced, hormone-sensitive prostate cancer or in castration-resistant disease. Evaluate testosterone levels regularly to confirm suppression (<50 ng/dL). If a maintenance dose is missed, take it as soon as remembered on the same day; do not take two doses to make up for a missed one. Resume therapy as soon as possible after a missed loading dose or multiple missed maintenance doses.

Storage

  • Store Rexigo 120 tablets in a cool, dry place below 30°C.
  • Keep the medication in its original blister packaging until use to protect from moisture and light.
  • Do not refrigerate or freeze.
  • Keep out of reach of children and dispose of unused tablets responsibly.

Possible Side Effects

  • Common: hot flashes, fatigue, diarrhea, musculoskeletal pain
  • Occasional: elevated liver enzymes, constipation, decreased libido
  • Long-term: reduced bone mineral density, metabolic changes, mood alterations
  • Cardiovascular: generally lower risk than injectable GnRH therapies, but monitor patients with heart disease history
  • Rare/Extended use: anemia, hyperglycemia

FAQs

Rexigo 120 offers oral delivery, rapid testosterone suppression without a flare, and a more favorable cardiovascular profile compared to traditional GnRH agonists.
Yes. Rexigo 120 can be taken with or without food, ideally at the same time each day for consistent absorption.
Yes. It is approved for continuous use in advanced prostate cancer and is generally well tolerated with proper monitoring.
If you miss a daily dose, take it as soon as you remember on the same day. Do not double up the next day. If multiple doses are missed, consult your healthcare provider about restarting the regimen.
No. Testosterone levels typically recover after discontinuation of Relugolix, unlike surgical castration or irreversible chemical castration approaches.

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