Estra 2mg, Estradiol Valerate, Women’s Health, Hormone Replacement Therapy, Online Pharmacy
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Estra 2mg Tablet

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Generic For PROGYNOVA
Active Ingredient ESTRADIOL VALERATE
Strength 2MG
Manufacturer GYNOSURE
Estra 2 28 tablets blister pack pink estradiol hormone therapy online pharmacy
Estra 2 28 tablets box packaging estradiol estrogen replacement medicine online pharmacy
Estra 2 28 tablets blister pack pink estradiol hormone therapy online pharmacy
Estra 2 28 tablets box packaging estradiol estrogen replacement medicine online pharmacy
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Product Description

Estra 2mg Tablet contains Estradiol Valerate, a synthetic estrogen ester that acts as a bioidentical hormone replacement. Once ingested or injected, it is converted into estradiol, the primary female sex hormone, restoring hormonal balance in estrogen-deficient states. Its long half-life and high bioavailability make it effective for managing a wide range of estrogen-related conditions including menopausal symptoms, menstrual irregularities, osteoporosis, and hormone-responsive cancers.

Indications & Uses

  • HORMONES & MENOPAUSAL SYMPTOMS > Menopausal Hormone Therapy Used to manage vasomotor instability such as hot flashes, mood swings, night sweats, and vaginal dryness in menopausal women.
  • FEMTECH > Menstrual Control Supports cycle regulation in patients with amenorrhea or premature menopause, especially in cases of ovarian failure.
  • FEMTECH > Vaginal & Urethral Atrophy Improves vaginal elasticity and lubrication by reversing estrogen depletion in urogenital tissues.
  • LIFESTYLE-RELATED DISEASES > Osteoporosis Estrogen supplementation slows bone turnover and prevents bone mass loss in postmenopausal women.
  • DISEASES/SYMPTOMS > Hypoestrogenism Restores hormonal function in patients with low estrogen due to surgical removal of ovaries, pituitary dysfunction, or genetic disorders.
  • AntiCancer Drugs > Prostate Cancer Applied in males to counteract testosterone, providing palliation in hormone-sensitive prostate carcinoma.
  • AntiCancer Drugs > Breast Cancer Utilized selectively in elderly women as a secondary endocrine therapy for hormone receptor-positive breast cancer.
  • AntiCancer Drugs > Others (for off-label hormonal modulation) Considered in off-label hormonal protocols, including gender-affirming therapy and treatment-resistant gynecologic disorders.

Benefits & Effectiveness

Estradiol Valerate exerts its pharmacological effects by binding to estrogen receptors in target tissues, promoting the transcription of genes involved in reproductive, skeletal, cardiovascular, and neural health. The drug modulates pituitary gonadotropin secretion, inhibits bone resorption, enhances collagen formation, and provides trophic support to estrogen-dependent tissues. When used oncologically, it participates in hormone-based suppression regimens.

Directions for Use

  • Postmenopausal Symptoms - Oral: 1–2 mg daily on a cyclic basis (3 weeks on, 1 week off), Transdermal Patch: Twice-weekly 0.0375–0.05 mg/day to start; maintenance 0.025–0.1 mg/day, Once-weekly 0.025 mg/day initially; titrate up to 0.1 mg/day, Gel: Divigel 0.25–1.25 mg/day to thigh, Metered-dose pump: Estrogel 0.52–0.75 mg/day to arm, Spray: Evamist 1.53 mg/spray; 1–3 sprays daily on forearm, Vaginal Ring: Femring delivers 0.05–0.1 mg/day over 90 days, IM Injection: Cypionate 1–5 mg IM every 3–4 weeks, Valerate 10–20 mg IM every 4 weeks
  • Atrophic Urethritis / Vaginitis - Use localized vaginal cream, tablet, or ring; systemic route may be used if systemic symptoms coexist
  • Hypoestrogenism (e.g., ovarian failure, gonadal dysgenesis) - Oral: 1–2 mg/day continuously, Transdermal or IM alternatives per same regimens above
  • Primary Ovarian Failure / Oophorectomy - Continuous estrogen therapy with regular reassessment; progestogen required in women with uterus
  • Osteoporosis Prevention - Oral: ≥0.5 mg/day; lowest effective dose should be used, Patch: Biweekly 0.025 mg/day, Weekly: Climara 0.025 mg/day, Menostar 0.014 mg/day, Should be reserved for patients unable to tolerate or respond to non-estrogen therapies
  • Breast Cancer (Advanced, Palliative) - Oral: 10 mg three times daily; used in hormone-receptor-positive cases where first-line therapy fails
  • Prostate Cancer (Palliative) - Oral: 1–2 mg three times daily, IM: 30 mg or more estradiol valerate every 1–2 weeks for androgen suppression
  • General Notes - Aim for the lowest effective dose and shortest treatment duration, Combine with a progestogen in women with an intact uterus to mitigate endometrial hyperplasia risk, Regularly assess therapy need and monitor for thromboembolic, hepatic, or breast-related complications

Storage

  • Store at temperatures below 25°C, protected from direct light and moisture.
  • Keep in original packaging until use. Do not freeze. Keep out of reach of children.

Possible Side Effects

  • Common: nausea, bloating, breast tenderness, headache, mood swings
  • Serious: deep vein thrombosis, stroke, myocardial infarction, liver dysfunction, gallstones
  • Report immediately: sudden vision loss, speech difficulty, limb swelling, or abnormal vaginal bleeding

FAQs

Estra contains Estradiol Valerate, a synthetic but bioidentical estrogen ester with prolonged activity and predictable absorption.
Duration varies based on indication; regular re-evaluation every 3–6 months is recommended.
Yes, particularly in prostate cancer management and gender-affirming hormone therapy under physician supervision.
Yes, it's commonly prescribed to restore hormonal balance and maintain bone and cardiovascular health in hypoestrogenic states.
If you have a uterus, a progestogen must be taken to protect the endometrial lining.

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