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| Generic For | FEMARA |
|---|---|
| Active Ingredient | LETROZOLE |
| Strength | 2.5MG |
| Manufacturer | HEALING PHARMA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 2 BOXES - 60 TABLETS | $ 1.27 | $ 76.00 |
$ 64.60
Apply ZARVY26 (-15%)
You save $ 11.40
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| 3 BOXES - 90 TABLETS | $ 1.26 | $ 113.50 |
$ 96.48
Apply ZARVY26 (-15%)
You save $ 17.03
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| ★ Best Value 6 BOXES - 180 TABLETS | $ 1.26 |
1% $ 228.00
$ 226.00
|
$ 192.10
Apply ZARVY26 (-15%)
You save $ 33.90
|
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Letroheal 2.5 is an oral formulation of letrozole 2.5mg, classified as a third-generation non-steroidal aromatase inhibitor (AI). It is primarily prescribed for hormone receptor-positive (HR+) breast cancer in postmenopausal women and functions by significantly lowering estrogen levels through inhibition of the aromatase enzyme.
Estrogen is a major driver of tumor growth in HR+ breast cancers, and Letroheal 2.5 helps to suppress disease progression and recurrence. The medication is effective as adjuvant therapy following surgery, neoadjuvant therapy to reduce tumor size prior to surgery, and as first-line treatment in advanced or metastatic stages—especially in combination with CDK4/6 inhibitors like ribociclib.
Beyond oncology, Letroheal has emerged as an alternative ovulation induction agent in reproductive medicine, offering additional benefits in women with infertility related to PCOS or ovulatory dysfunction.
AntiCancer Drugs > HR+ Breast Cancer in Postmenopausal Women
Letrozole is widely used for endocrine management of HR+/HER2- breast cancer in postmenopausal patients. It serves as a primary systemic therapy after surgery and is also employed in the neoadjuvant setting. It is often continued for 5–10 years to minimize recurrence risk in early-stage disease.
AntiCancer Drugs > Advanced or Metastatic Breast Cancer
Letroheal 2.5 is used in combination with agents like fulvestrant, palbociclib, or ribociclib to improve survival outcomes in patients with advanced disease. Its role in hormone-sensitive metastatic breast cancer is well established and supported by long-term clinical evidence.
FEMTECH > Ovulation Induction for Infertility
Letrozole is an effective off-label therapy for inducing ovulation in women with anovulation or PCOS. Its mechanism promotes FSH release by lowering estrogen-mediated negative feedback, thereby enhancing follicular development. It is often preferred over clomiphene due to improved pregnancy rates and lower risk of multiple gestation.
Letrozole works by inhibiting the aromatase enzyme that catalyzes the final step in estrogen biosynthesis. This leads to a systemic reduction in circulating estrogen levels, thereby depriving HR+ breast cancer cells of their hormonal stimulus.
Letrozole does not impair adrenal or ovarian function, making it a selective and well-tolerated agent for long-term use.
In fertility care, it enhances the body’s own hormonal signals for ovulation without excessive stimulation, reducing the risk of ovarian hyperstimulation.
The pharmacokinetics of letrozole support once-daily dosing with consistent therapeutic effect.
Standard Breast Cancer Dose
→ Letrozole: 2.5 mg orally once daily
→ Taken without interruption throughout the 28-day cycle
→ Therapy may continue for 5–10 years based on risk assessment and clinical judgment
→ Can be initiated as monotherapy or in combination with other endocrine agents
Combination Therapy
→ Ribociclib: 600 mg orally once daily for 21 days, followed by 7 days off
→ Letrozole: 2.5 mg orally once daily continuously (no off days) during the same 28-day cycle
→ Appropriate for pre-, peri-, and postmenopausal women when paired with ovarian suppression
Ovulation Induction (Off-label Use)
→ Typical dose: 2.5–5 mg once daily for 5 days, starting on day 3 or 5 of the menstrual cycle
→ Follicular monitoring via ultrasound is recommended
→ Dosage may be adjusted in subsequent cycles depending on response
Administration Tips
→ Take at the same time each day, with or without food
→ If a dose is missed, take it as soon as remembered unless it’s close to the next scheduled dose. Do not double the next dose
→ Patients should have bone mineral density and lipid levels monitored during extended treatment
Store below 25°C in a dry place away from moisture and direct light
Keep in original blister packaging until use
Do not store in bathroom cabinets or humid environments
Keep out of reach of children
Dispose responsibly after expiry
Common: hot flashes, joint stiffness, fatigue, nausea, dizziness
Less common: hypercholesterolemia, insomnia, weight gain, headache
Rare: osteoporosis, thromboembolic events, hepatic enzyme elevation
Seek immediate medical help if symptoms such as chest pain, jaundice, or sudden vision changes occur.
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