Monurol Granule 3g, Fosfomycin, Antibiotics & Infections, Online Pharmacy, ZarvyPharm
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ANTIBIOTICS Urinary Tract Infection

Monurol Granule 3g - Sachet

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Drug Type Original
Active Ingredient FOSFOMYCIN
Strength 3GM
Manufacturer ZAMBON
Monurol Granule 3g box with single sachet, front-facing label readable
Monurol Granule 3g sachet close-up, packet design and text visible
Monurol Granule 3g box and sachet arranged flat, product name clearly shown
Monurol Granule 3g box with single sachet, front-facing label readable
Monurol Granule 3g sachet close-up, packet design and text visible
Monurol Granule 3g box and sachet arranged flat, product name clearly shown
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Product Description

Monurol Granule 3g Sachet contains fosfomycin, a broad-spectrum bactericidal antibiotic that targets bacterial cell wall synthesis by inactivating enolpyruvyl transferase (MurA). This prevents peptidoglycan formation, leading to bacterial cell death.

Its single-dose oral formulation provides high urinary concentrations for 48–72 hours, making it highly effective for uncomplicated urinary tract infections (UTIs).

Fosfomycin is also valuable against resistant pathogens, including ESBL-producing E. coli and carbapenem-resistant Enterobacteriaceae (CRE), and is used intravenously in hospital-acquired infections like sepsis or pneumonia caused by multidrug-resistant organisms.

Indications & Uses

  • Antibiotics & Infections | Urinary Tract Infection (UTI): First-line therapy for acute uncomplicated cystitis in women. Single-dose oral administration ensures bactericidal urinary levels with minimal systemic exposure.
  • Systemic Infection: Intravenous fosfomycin is reserved for complex infections involving multidrug-resistant pathogens, often in combination therapy for bacteremia, ventilator-associated pneumonia, and intra-abdominal abscesses.
  • MDR Organism Coverage: Effective against ESBL-producing E. coli, CRE, and other resistant uropathogens, preserving other antibiotic options and reducing carbapenem reliance.
  • Combination Therapy: Enhances efficacy against MRSA, Pseudomonas, and CRE when combined with beta-lactams or aminoglycosides, reducing resistance development.
  • Outpatient Convenience: Ideal for outpatient cystitis due to single-dose oral format, improving adherence and minimizing pill burden.

Benefits & Effectiveness

  • Mechanism: Inhibits MurA enzyme, blocking the first step of peptidoglycan synthesis → rapid bactericidal action.
  • Spectrum: Broad-spectrum activity against Gram-negative and Gram-positive bacteria, including resistant strains.
  • Resistance profile: Unique mechanism prevents cross-resistance, supporting monotherapy or synergistic combination protocols for resistant infections.

Directions for Use

  • Adults – Acute Uncomplicated Cystitis: 3 g orally once (single dose).
  • Administration: Dissolve contents of one sachet in a glass of water and take immediately.
  • Timing: Take on an empty stomach, preferably at bedtime after urination.
  • Limitations: Not recommended for pyelonephritis or perinephric abscess.
  • Indication: Only for lower urinary tract infections caused by susceptible E. coli or Enterococcus faecalis.
  • Repeat dosing: Do not repeat dose unless directed by a physician.
  • Follow-up: If symptoms persist >72 hours, seek further evaluation.
  • Drug interactions: Avoid co-administering drugs that reduce urinary concentration or increase renal excretion.
  • Renal/Hepatic Impairment: Use caution in significant renal dysfunction; dose adjustment generally not needed for single-dose therapy.

Storage

  • Storage condition: Store below 25 °C in a dry place, away from moisture and direct sunlight.
  • Packaging: Keep sachets sealed until use.
  • Safety: Keep out of reach of children.

Possible Side Effects

  • Common: headache, diarrhea, nausea, abdominal pain, dizziness.
  • Less common: vulvovaginitis, fatigue, back pain, flatulence.
  • Rare but serious: allergic reactions including rash, angioedema, or anaphylaxis.
  • Action: Discontinue immediately and consult a doctor if rash, swelling, or difficulty breathing occurs.

FAQs

It is used to treat acute uncomplicated urinary tract infections (cystitis) in women caused by susceptible bacteria.
A single 3g dose is typically sufficient. Do not repeat unless directed by your doctor.
No. It is not effective for upper urinary tract infections such as pyelonephritis or kidney abscesses.
Dissolve the granules in a glass of water and take on an empty stomach, preferably before bedtime after urinating.
Yes. It is active against many ESBL-producing bacteria and may be used in combination therapy for multidrug-resistant infections.

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