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Review Details
(10)
| Drug Type | Original |
|---|---|
| Active Ingredient | SAXAGLIPTIN|METFORMIN |
| Strength | 5MG|1000MG |
| Manufacturer | ASTRAZENECA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 28 TABLETS | $ 1.88 | $ 52.70 |
$ 44.80
Apply ZARVY26 (-15%)
You save $ 7.91
|
||
| 2 BOXES - 56 TABLETS | $ 1.69 |
10% $ 105.40
$ 94.60
|
$ 80.41
Apply ZARVY26 (-15%)
You save $ 14.19
|
||
| ★ Best Value 3 BOXES - 84 TABLETS | $ 1.50 |
20% $ 158.10
$ 126.00
|
$ 107.10
Apply ZARVY26 (-15%)
You save $ 18.90
|
Reference information will be available soon.
Kombiglyze XR 5/1000 is an original branded medication developed by AstraZeneca for the management of Type 2 Diabetes. It combines Saxagliptin (DPP-4 Inhibitor) 5mg and Metformin (First-Line Therapy) 1000mg in an extended-release (XR) formulation for sustained Glycemic Control. This dual-action therapy helps regulate blood sugar levels by enhancing insulin secretion, reducing hepatic glucose production, and improving insulin sensitivity. Additionally, Kombiglyze XR 5/1000 supports Cardiovascular Health by stabilizing glucose metabolism and lowering vascular stress associated with diabetes.
- Blood Sugar Regulation: A dual-mechanism approach that enhances insulin secretion and reduces hepatic glucose production for stable Glycemic Control. - First-Line Diabetes Treatment: Metformin improves insulin sensitivity, decreases glucose absorption, and maintains long-term metabolic stability. - DPP-4 Inhibitor Action: Saxagliptin prevents incretin hormone breakdown, stimulating post-meal insulin release and suppressing glucose spikes. - Extended-Release Formulation: Provides sustained blood sugar control throughout the day with fewer gastrointestinal side effects. - Cardiovascular Protection: Helps prevent Cardiovascular Diseases by reducing vascular inflammation and stabilizing blood sugar levels.
Kombiglyze XR 5/1000 works through two primary mechanisms: - Saxagliptin (DPP-4 Inhibitor): Enhances insulin secretion, prevents excess glucose release, and stabilizes post-meal glucose levels. - Metformin (First-Line Therapy): Reduces hepatic glucose production, increases insulin efficiency, and improves Glycemic Control. The extended-release formulation allows for gradual absorption, providing long-lasting metabolic support and minimizing gastrointestinal side effects.
For Diabetes > First Line Therapies: Metformin - Kombiglyze XR 5/1000 is prescribed for type 2 diabetes management in patients needing dual therapy. - Standard dosage: One tablet once daily, preferably with the evening meal to minimize stomach discomfort. - Metformin lowers liver glucose production and enhances insulin sensitivity for better blood sugar control. - Extended-release formulation ensures gradual drug release, reducing the risk of gastrointestinal side effects. - Regular blood sugar monitoring is necessary for maintaining optimal glycemic control. For Diabetes > DPP-4 Inhibitors - Saxagliptin inhibits DPP-4 enzyme, enhancing insulin secretion and reducing liver glucose production. - Effective in lowering post-meal glucose spikes and maintaining steady blood sugar levels. - Can be combined with Metformin for improved glycemic outcomes. - Lower risk of hypoglycemia compared to other diabetes medications. For Diet > Glycemic Control - Stabilizes blood sugar levels, preventing post-meal glucose surges. - Works best when combined with a healthy diet and regular exercise. - Enhances insulin response, supporting long-term diabetes management. For Lifestyle-Related Diseases > Cardiovascular Diseases - Saxagliptin & Metformin combination therapy may provide cardiovascular benefits. - May help reduce heart disease risk by improving vascular function and blood flow. - Supports weight management, which is essential for maintaining heart health. Administration - Take once daily with the evening meal to reduce stomach discomfort. - Swallow whole—do not crush or chew, as it is an extended-release (XR) formulation. - Maintain adequate hydration to prevent dehydration. - Do not double the dose if one is missed. - Consult a doctor for dosage adjustments based on kidney function and blood sugar levels.
- Store in a cool, dry place, away from heat and moisture. - Keep in original packaging to maintain potency and effectiveness. - Ensure it is out of reach of children and pets.
While Kombiglyze XR 5/1000 is well tolerated, some users may experience: - Mild gastrointestinal discomfort (nausea, bloating, diarrhea) due to Metformin. - Headache or dizziness due to Saxagliptin. - Upper respiratory infections (common with DPP-4 inhibitors). - Hypoglycemia when combined with other antidiabetic medications. - Fatigue or weakness in rare cases. Serious side effects, such as lactic acidosis or pancreatitis, require immediate medical attention.
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