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| Generic For | CRESTOR |
|---|---|
| Active Ingredient | ROSUVASTATIN |
| Strength | 5MG |
| Manufacturer | CIPLA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 150 TABLETS | $ 0.52 | $ 78.00 |
$ 66.30
Apply ZARVY26 (-15%)
You save $ 11.70
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| 2 BOXES - 300 TABLETS | $ 0.49 |
5% $ 156.00
$ 147.90
|
$ 125.72
Apply ZARVY26 (-15%)
You save $ 22.19
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| ★ Best Value 3 BOXES - 450 TABLETS | $ 0.48 |
7% $ 234.00
$ 217.90
|
$ 185.22
Apply ZARVY26 (-15%)
You save $ 32.69
|
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Rosulip 5mg contains 5mg of Rosuvastatin, a high-potency statin classified as an HMG-CoA reductase inhibitor. It is widely used for the treatment of hyperlipidemia and the primary and secondary prevention of cardiovascular events. Rosuvastatin functions by inhibiting hepatic cholesterol biosynthesis, which leads to upregulation of LDL receptors and accelerated clearance of circulating LDL particles. The 5mg dose is often selected as a starting point for statin-naïve individuals, patients with mild lipid abnormalities, elderly populations, or pediatric patients requiring precise titration. Rosulip 5 not only reduces LDL cholesterol and triglycerides but also increases HDL levels, contributing to a comprehensive improvement in lipid profile and a significant reduction in cardiovascular risk.
- Lifestyle-related Diseases > Hyperlipidemia Indicated for primary hyperlipidemia, mixed dyslipidemia, and hypertriglyceridemia. Helps lower LDL-C, total cholesterol, triglycerides, and ApoB while increasing HDL-C levels. > Cardiovascular Diseases Used to reduce the risk of myocardial infarction, stroke, and the need for revascularization in patients with elevated cardiovascular risk, including those with diabetes or atherosclerosis. > Cerebral Infarction & Myocardial Infarction Prevention Clinically proven to lower the incidence of ischemic stroke and heart attack in high-risk populations, including older adults and those with systemic inflammation or prior vascular events.
Rosuvastatin competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. This leads to a cascade effect resulting in increased LDL receptor expression and enhanced clearance of LDL-C from plasma. Rosuvastatin also lowers triglycerides and raises HDL-C, contributing to a favorable shift in the overall lipid profile. Unlike other statins, Rosuvastatin is not extensively metabolized via CYP450 enzymes, reducing the risk of drug-drug interactions. It is particularly effective in reducing high-sensitivity CRP and promoting plaque stability. The 5mg strength allows for individualized therapy in sensitive groups such as pediatric, geriatric, and renal-impaired patients.
General Hyperlipidemia / Mixed Dyslipidemia / Atherosclerosis / Hypertriglyceridemia: → Initial dose: 10–20 mg once daily → Maintenance dose: 5–40 mg once daily → Maximum dose: 40 mg/day (reserved for patients who do not meet LDL goals with 20 mg) → Lipid levels should be reassessed and dose adjusted every 2–4 weeks Hyperlipoproteinemia Type III (Dysbetalipoproteinemia): → Same dosing as general use → Effective in lowering beta-VLDL and IDL cholesterol fractions Homozygous Familial Hypercholesterolemia (HoFH): → Initial dose: 20 mg once daily → Maintenance: 5–40 mg/day → May be used alone or with LDL apheresis in severe familial cases Primary Prevention of Cardiovascular Disease (CVD): → Initial dose: 10–20 mg once daily → Maximum: 40 mg/day → For men aged ≥50 and women ≥60 with hsCRP ≥2 mg/L and at least one additional CVD risk factor Pediatric Use – Heterozygous Familial Hypercholesterolemia (HeFH): → 8–9 years: 5–10 mg once daily (max 10 mg) → 10–17 years: 5–20 mg once daily (max 20 mg) → Reassess at intervals of ≥4 weeks Pediatric Use – Homozygous Familial Hypercholesterolemia (HoFH): → ≥7 years: 20 mg once daily → May be used alone or with other lipid-lowering agents Should be taken once daily at the same time each day. May be taken with or without food. Therapy must be combined with a cholesterol-lowering diet and lifestyle modifications.
Store in a dry, cool location below 25°C. Keep away from moisture and direct sunlight. Do not store in bathroom cabinets or high humidity areas. Keep out of reach of children and animals.
Common: headache, muscle aches, abdominal pain, constipation, nausea Less common: dizziness, sleep disturbances, elevated liver enzymes Serious but rare: rhabdomyolysis, hepatic dysfunction, proteinuria Seek immediate medical attention if symptoms like muscle weakness, dark urine, or yellowing of the skin appear.
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