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| Generic For | TEGRETOL |
|---|---|
| Active Ingredient | CARBAMAZEPINE |
| Strength | 300MG |
| Manufacturer | ABBOTT |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 150 TABLETS | $ 0.33 | $ 49.90 |
$ 42.42
Apply ZARVY26 (-15%)
You save $ 7.49
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| 2 BOXES - 300 TABLETS | $ 0.34 | $ 101.90 |
$ 86.62
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You save $ 15.29
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| ★ Best Value 3 BOXES - 450 TABLETS | $ 0.34 | $ 151.90 |
$ 129.12
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You save $ 22.79
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Mazetol SR 300 is a sustained-release formulation of carbamazepine 300mg designed to maintain stable plasma levels throughout the day. This formulation is particularly beneficial for managing chronic neurological and psychiatric conditions that require consistent control of symptoms. Its gradual release profile reduces dosing frequency and improves adherence, making it a reliable choice for long-term therapy in epilepsy, bipolar disorder, and chronic neuropathic pain.
Epilepsy
Mazetol SR 300 is indicated for the treatment of both partial-onset and generalized tonic-clonic seizures. Its slow-release mechanism ensures stable drug levels, minimizing peak-related side effects and improving seizure control consistency.
Bipolar Disorder
This medication is commonly prescribed as a mood stabilizer in patients with bipolar I disorder, especially for the prevention of manic or hypomanic episodes. It is often used when lithium is not tolerated or as part of combination therapy for resistant mood symptoms.
Depression, Anxiety, PTSD
In some cases, Mazetol SR 300 is used off-label to support emotional stability in patients with co-occurring depression, anxiety, or PTSD. It contributes to the regulation of mood and can reduce emotional reactivity and impulsivity.
Neuropathic Pain
Mazetol SR 300 is effective for neuropathic conditions such as trigeminal neuralgia and diabetic neuropathy. It helps reduce nerve pain by stabilizing overactive sensory neurons and decreasing signal transmission in damaged nerves.
Carbamazepine works by blocking voltage-gated sodium channels in overactive neurons, thereby reducing the repetitive firing that causes seizures, mood instability, and chronic pain. It is especially effective for patients who require continuous symptom management and has proven efficacy across neurological and psychiatric indications.
Adult Dosing Summary
Epilepsy – IR Form: Start at 200 mg twice daily (or 100 mg QID oral suspension). Increase weekly by up to 200 mg/day in divided doses (TID or QID). Maintenance: 800–1200 mg/day; Max: 1600 mg/day.
ER Form: Same total daily dose as IR, divided BID; titrate similarly.
Trigeminal Neuralgia – Start at 100 mg BID (or 50 mg QID suspension). Increase up to 200 mg/day until pain is controlled. Maintenance: 400–800 mg/day; Max: 1200 mg/day. Reassess therapy every 3 months for possible dose reduction.
Bipolar Disorder / Mania (ER Capsules) – Start at 200 mg BID. Titrate by 200 mg/day to optimal response. Max: 1600 mg/day.
Pediatric Dosing Summary
<6 Years – 10–20 mg/kg/day divided BID–QID. Titrate weekly; Max: 35 mg/kg/day.
6–12 Years – Start at 100 mg BID (or 100 mg QID suspension). Titrate weekly by up to 100 mg/day. Maintenance: 400–800 mg/day; Max: 1000 mg/day.
>12 Years – Start at 200 mg BID (or 100 mg QID suspension). Titrate weekly by up to 200 mg/day. Maintenance: 800–1200 mg/day. Max: 1000 mg/day (12–15 yrs), 1200 mg/day (>15 yrs).
Additional Considerations
Switching IR → ER: Use same total daily dose, divided BID. Monitor closely.
Switching to Suspension: Same daily dose, increase frequency (TID or QID).
Polytherapy: Add carbamazepine gradually; adjust other AEDs as needed (e.g., phenytoin may require dose increase).
Monitoring: Plasma level testing aids in optimizing dosage, ensuring compliance, and identifying interactions.
Not effective for absence seizures; may worsen generalized seizures in some patients.
Store in a cool, dry place below 25°C. Keep the tablets in their original packaging to protect from moisture and light. Ensure the medication is kept out of reach of children.
Common side effects include dizziness, drowsiness, nausea, and mild gastrointestinal upset.
More serious adverse effects may involve hepatic enzyme elevation, blood dyscrasias (including aplastic anemia and agranulocytosis), skin hypersensitivity reactions such as Stevens-Johnson Syndrome, and hyponatremia.
Regular monitoring of liver function and blood parameters is essential during prolonged use.
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