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| Generic For | TEGRETOL |
|---|---|
| Active Ingredient | CARBAMAZEPINE |
| Strength | 300MG |
| Manufacturer | INTAS PHARMACEUTICALS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.40 | $ 39.90 |
$ 33.92
Apply ZARVY26 (-15%)
You save $ 5.99
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| 2 BOXES - 200 TABLETS | $ 0.42 | $ 83.90 |
$ 71.32
Apply ZARVY26 (-15%)
You save $ 12.59
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.41 | $ 122.90 |
$ 104.47
Apply ZARVY26 (-15%)
You save $ 18.44
|
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Zen Retard 300 is a controlled-release anticonvulsant formulation containing 300mg of carbamazepine, tailored to provide stable plasma concentrations for patients managing epilepsy, bipolar disorder, or neuropathic pain.
Its extended-release mechanism is designed to reduce peak-trough fluctuations that can lead to unwanted side effects or breakthrough symptoms, especially in chronic therapy.
Recognized globally as a reliable alternative to immediate-release carbamazepine, this formulation ensures more consistent symptom control with improved patient adherence.
Zen Retard 300 is part of the carbamazepine class and is often utilized when patients are unresponsive to or intolerant of lithium or valproate therapies.
Epilepsy
Zen Retard 300 suppresses the abnormal electrical activity in the brain responsible for partial seizures and generalized tonic-clonic seizures. It reduces both the frequency and intensity of seizures, making it a cornerstone therapy in long-term seizure control. The extended-release delivery is particularly beneficial for maintaining therapeutic levels during sleep or long dosing intervals.
Bipolar Disorder
As a mood stabilizer, Zen Retard 300 helps prevent manic and hypomanic episodes. It is especially useful in patients with rapid cycling or those who experience side effects from lithium. It supports emotional balance, stabilizing unpredictable shifts in mood over time.
Depression, Anxiety, PTSD
Although not the first-line treatment, carbamazepine is sometimes used off-label for mood instability associated with PTSD, anxiety, or bipolar-related depression. It helps patients regain emotional steadiness and reduce hypersensitivity to stressors.
Neuropathic Pain
Zen Retard 300 provides significant relief in neuropathic pain disorders, such as trigeminal neuralgia and diabetic neuropathy. It dampens hyperactive pain pathways in the nervous system, allowing better management of chronic, resistant nerve pain.
Carbamazepine works by inhibiting voltage-gated sodium channels on overactive neurons, preventing the repetitive firing that causes seizures and mood episodes. This stabilization of neural signaling extends to pain pathways, making it effective for nerve-related pain. The extended-release mechanism ensures a controlled absorption rate, leading to fewer peaks and troughs in blood levels, which is key for steady symptom relief and improved tolerability.
Adult Dosing Summary
Epilepsy (IR Form) – Start at 200 mg twice daily. Increase weekly by up to 200 mg/day in divided doses (TID or QID). Maintenance: 800–1200 mg/day. Maximum: 1600 mg/day.
Epilepsy (ER Form) – Same total daily dose as IR, divided BID. Titrate similarly to IR.
Trigeminal Neuralgia – Start at 100 mg BID. Titrate up to 200 mg/day until pain is controlled. Maintenance: 400–800 mg/day. Maximum: 1200 mg/day. Reassess therapy every 3 months.
Bipolar Disorder / Mania – Start at 200 mg BID. Increase by 200 mg/day as needed. Maximum: 1600 mg/day.
Pediatric Dosing Summary
<6 Years – 10–20 mg/kg/day divided BID–QID. Titrate weekly. Maximum: 35 mg/kg/day.
6–12 Years – Start at 100 mg BID. Titrate by up to 100 mg/day. Maintenance: 400–800 mg/day. Maximum: 1000 mg/day.
>12 Years – Start at 200 mg BID. Titrate by up to 200 mg/day. Maintenance: 800–1200 mg/day. Maximum: 1000 mg/day (12–15 yrs), 1200 mg/day (>15 yrs).
Additional Considerations
When switching from immediate-release to extended-release, maintain the same daily dose split BID.
Suspension requires more frequent dosing (TID or QID).
In polytherapy, titrate carbamazepine gradually and monitor for drug interactions.
Plasma level monitoring improves dosage accuracy and detects non-adherence.
Not suitable for absence seizures and may worsen generalized seizures in some patients.
Store in a cool, dry place below 25°C. Protect from direct sunlight and moisture. Keep in the original blister packaging and out of reach of children. Do not use tablets if discolored or compromised.
Common side effects include dizziness, drowsiness, nausea, blurred vision, and unsteadiness. Patients may also experience dry mouth or mild gastrointestinal discomfort.
Rare but serious adverse reactions include hyponatremia, liver dysfunction, aplastic anemia, agranulocytosis, and severe dermatologic reactions like Stevens-Johnson syndrome.
Routine monitoring of liver enzymes, blood counts, and serum sodium is recommended, particularly during the initial phase of therapy or when adjusting the dose.
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