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| Generic For | TEGRETOL |
|---|---|
| Active Ingredient | CARBAMAZEPINE |
| Strength | 400MG |
| Manufacturer | INTAS PHARMACEUTICALS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.35 | $ 34.90 |
$ 29.67
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| 2 BOXES - 200 TABLETS | $ 0.33 |
4% $ 69.80
$ 66.90
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$ 56.87
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.36 | $ 106.90 |
$ 90.87
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Zen Retard 400 is a sustained-release antiepileptic formulation containing 400mg of carbamazepine. It is designed to provide stable plasma concentrations throughout the day, improving compliance and reducing dosing frequency. This formulation is particularly suitable for chronic neurological and psychiatric conditions requiring steady-state control.
Sleep & Mental Health > Epilepsy
Zen Retard 400 is widely used to treat partial seizures and generalized tonic-clonic seizures by reducing abnormal electrical discharges in the brain. Its extended-release mechanism ensures long-lasting efficacy and consistent therapeutic levels.
Sleep & Mental Health > Bipolar Disorder
Zen Retard 400 functions as a mood stabilizer, frequently prescribed in the acute and maintenance treatment of bipolar I disorder. It helps prevent manic or hypomanic episodes and is often used when lithium is ineffective or poorly tolerated.
Sleep & Mental Health > Depression, Anxiety, PTSD
Though not a first-line agent, carbamazepine may be prescribed adjunctively in cases of treatment-resistant mood disorders, including bipolar depression and PTSD. It helps regulate mood lability and impulsive behavior.
Painkillers & Headache > Neuropathic Pain
Zen Retard 400 is effective for nerve-related pain such as trigeminal neuralgia and diabetic neuropathy. It reduces pain transmission by modulating sodium channels and stabilizing hyperexcited neurons.
Carbamazepine exerts its therapeutic effect by inhibiting voltage-gated sodium channels, stabilizing overactive neural membranes, and reducing repetitive neuronal firing. This mechanism provides effective seizure control, supports mood regulation, and offers relief from neuropathic pain.
Adult Dosing
• Epilepsy
→ Start: 200 mg BID (or 100 mg QID suspension)
→ Titration: Increase up to 200 mg/day weekly
→ Maintenance: 800–1200 mg/day
→ Maximum: 1600 mg/day
• Trigeminal Neuralgia
→ Start: 100 mg BID (or 50 mg QID suspension)
→ Increase gradually based on response
→ Maintenance: 400–800 mg/day
→ Maximum: 1200 mg/day
• Bipolar Disorder
→ Start: 200 mg BID (extended release)
→ Increase by 200 mg/day to achieve therapeutic effect
→ Maximum: 1600 mg/day
Pediatric Dosing
• <6 Years
→ 10–20 mg/kg/day divided BID–QID
→ Maximum: 35 mg/kg/day
• 6–12 Years
→ Start: 100 mg BID (or QID suspension)
→ Titrate by 100 mg/week
→ Maintenance: 400–800 mg/day
→ Maximum: 1000 mg/day
• >12 Years
→ Start: 200 mg BID (or 100 mg QID)
→ Titrate weekly by up to 200 mg/day
→ Maximum: 1000–1200 mg/day
Additional Considerations
→ Switching from IR to ER: Use same daily dose divided BID
→ Switching to suspension: Increase frequency
→ Polytherapy: Add gradually and adjust other AEDs
→ Monitoring: Plasma levels, liver function, and blood count required
→ Not effective for absence seizures
Common side effects
→ Dizziness
→ Drowsiness
→ Nausea
→ Blurred vision
→ Unsteadiness
Rare but serious side effects
→ Liver enzyme elevation
→ Bone marrow suppression
→ Skin rashes
→ Hyponatremia
Precautions / Monitoring
→ Regular blood monitoring is recommended during prolonged therapy.
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