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| Generic For | TEGRETOL |
|---|---|
| Active Ingredient | CARBAMAZEPINE |
| Strength | 400MG |
| Manufacturer | SUN PHARMA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.35 | $ 34.90 |
$ 29.67
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| 2 BOXES - 200 TABLETS | $ 0.33 |
4% $ 69.80
$ 66.90
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$ 56.87
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.36 | $ 106.90 |
$ 90.87
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Zeptol CR 400 is a sustained-release antiepileptic medication containing 400mg of carbamazepine. It is commonly used to control seizures, stabilize mood in bipolar disorder, and treat neuropathic pain. Its extended-release formulation ensures steady therapeutic plasma levels over 12 to 24 hours, reducing the need for frequent dosing and improving patient adherence. This makes it especially beneficial for individuals requiring long-term, stable management of neurological or psychiatric conditions.
Sleep & Mental Health > Epilepsy
Zeptol CR 400 is widely used to treat partial seizures and generalized tonic-clonic seizures by reducing excessive electrical activity in the brain. It is considered a frontline agent in epilepsy management.
Sleep & Mental Health > Bipolar Disorder
As a mood stabilizer, Zeptol CR 400 is frequently used in bipolar I disorder to manage acute manic episodes and prevent recurrence. It is particularly effective for patients who do not tolerate lithium well.
Sleep & Mental Health > Depression, Anxiety, PTSD
Although not a first-line treatment, carbamazepine may be used adjunctively in mood disorders with emotional instability, such as PTSD and treatment-resistant depression.
Painkillers & Headache > Neuropathic Pain
Zeptol CR 400 provides relief for nerve-related pain conditions like trigeminal neuralgia and diabetic neuropathy. It modulates nerve signal transmission and is preferred in chronic pain not responsive to conventional analgesics.
Carbamazepine stabilizes hyperexcited nerve membranes by blocking voltage-gated sodium channels, thereby reducing abnormal electrical activity. This effect helps control seizures, balance mood swings, and alleviate chronic neuropathic pain. Its controlled-release mechanism minimizes drug level fluctuations and supports consistent symptom control.
Adult Dosing
• Epilepsy
→ Start: 200 mg BID (or 100 mg QID suspension)
→ Titration: Increase up to 200 mg/day weekly
→ Maintenance: 800–1200 mg/day
→ Maximum: 1600 mg/day
• Trigeminal Neuralgia
→ Start: 100 mg BID
→ Increase gradually to control pain (maximum: 1200 mg/day)
→ Reassess every 3 months
• Bipolar Disorder
→ Start: 200 mg BID
→ Titrate by 200 mg/day based on clinical response
→ Maximum: 1600 mg/day
Pediatric Dosing
• <6 Years
→ 10–20 mg/kg/day divided BID–QID
→ Maximum: 35 mg/kg/day
• 6–12 Years
→ Start: 100 mg BID
→ Titrate by 100 mg/week
→ Maintenance: 400–800 mg/day
→ Maximum: 1000 mg/day
• >12 Years
→ Start: 200 mg BID
→ Titrate by 200 mg/week
→ Maintenance: 800–1200 mg/day
→ Maximum: 1000–1200 mg/day
Additional Considerations
→ Switching IR → ER: Use the same total daily dose, divided BID
→ Switching to suspension: Increase frequency (TID or QID)
→ Polytherapy: Titrate gradually and adjust other AEDs as needed
→ Monitoring: Plasma drug levels, liver function tests (LFTs), and electrolytes
→ Not effective for absence seizures; may worsen some generalized seizure types
Common side effects
→ Dizziness
→ Sedation
→ Nausea
→ Blurred vision
→ Unsteadiness
Rare but serious side effects
→ Leukopenia
→ Hyponatremia
→ Liver enzyme elevation
→ Severe dermatological reactions (e.g., Stevens-Johnson syndrome)
Precautions / Monitoring
→ Regular monitoring of blood counts, electrolytes, and liver function is strongly advised during therapy.
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