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| Generic For | TEGRETOL |
|---|---|
| Active Ingredient | CARBAMAZEPINE |
| Strength | 200MG |
| Manufacturer | INTAS PHARMACEUTICALS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.22 | $ 21.90 |
$ 18.62
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| 2 BOXES - 200 TABLETS | $ 0.20 |
9% $ 43.80
$ 39.90
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$ 33.92
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.21 |
6% $ 65.70
$ 61.90
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$ 52.61
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Zen 200 is an immediate-release formulation of carbamazepine 200mg, a well-established anticonvulsant and mood stabilizer. It is commonly prescribed for neurological and psychiatric conditions requiring long-term control, including epilepsy, bipolar disorder, and neuropathic pain. This formulation offers flexible dosing, rapid onset, and is suitable for titration-based adjustments, making it ideal for both monotherapy and adjunctive use in complex treatment regimens.
Epilepsy
Zen 200 effectively manages focal and generalized tonic-clonic seizures by stabilizing hyperexcitable neuronal circuits. It is used as a first-line therapy and is also effective in patients resistant to other antiepileptics.
Bipolar Disorder
Zen 200 is often employed as a mood-stabilizing agent for the acute and maintenance treatment of mania and hypomania in bipolar disorder. Its rapid symptom control and long-term efficacy make it a preferred option when lithium is unsuitable.
Depression, Anxiety, PTSD
While not formally indicated, Zen 200 is sometimes used adjunctively in mood disorders, especially when symptoms include emotional lability, impulsivity, or comorbid PTSD-related dysregulation.
Neuropathic Pain
Zen 200 is clinically effective for managing trigeminal neuralgia and other nerve-related pain syndromes by inhibiting pain signal transmission within damaged or hypersensitized sensory pathways.
Carbamazepine works by blocking voltage-gated sodium channels, thereby suppressing high-frequency neuronal firing associated with seizures, mood instability, and chronic pain. Its pharmacological profile supports broad neuropsychiatric use, including anticonvulsant, mood-stabilizing, and analgesic effects.
Adult Dosing Summary
Epilepsy – IR Form: Start at 200 mg twice daily (or 100 mg QID oral suspension). Increase weekly by up to 200 mg/day in divided doses (TID or QID). Maintenance: 800–1200 mg/day; Max: 1600 mg/day.
Trigeminal Neuralgia – Start at 100 mg BID (or 50 mg QID suspension). Increase up to 200 mg/day until pain is controlled. Maintenance: 400–800 mg/day; Max: 1200 mg/day. Reassess therapy every 3 months for dose reduction.
Bipolar Disorder / Mania (ER Capsules) – Start at 200 mg BID. Titrate by 200 mg/day to optimal response. Max: 1600 mg/day.
Pediatric Dosing Summary
<6 Years – 10–20 mg/kg/day divided BID–QID. Titrate weekly; Max: 35 mg/kg/day.
6–12 Years – Start at 100 mg BID (or 100 mg QID suspension). Titrate weekly by up to 100 mg/day. Maintenance: 400–800 mg/day; Max: 1000 mg/day.
>12 Years – Start at 200 mg BID (or 100 mg QID suspension). Titrate weekly by up to 200 mg/day. Maintenance: 800–1200 mg/day. Max: 1000 mg/day (12–15 yrs), 1200 mg/day (>15 yrs).
Additional Considerations
Switching IR → ER: Use same total daily dose, divided BID. Monitor closely.
Switching to Suspension: Same daily dose, increase frequency (TID or QID).
Polytherapy: Add carbamazepine gradually; adjust other AEDs as needed (e.g., phenytoin may require dose increase).
Monitoring: Plasma levels helpful for optimizing dosage, confirming compliance, and identifying interactions.
Not effective for absence seizures; may worsen generalized seizures in some patients.
Store in a cool, dry place below 25°C, protected from direct sunlight and moisture. Keep out of reach of children and avoid storage in humid areas like bathrooms.
Common side effects may include dizziness, fatigue, unsteadiness, nausea, and visual disturbances.
More serious but less frequent risks include hepatic dysfunction, leukopenia, hyponatremia, skin hypersensitivity reactions, and rare blood dyscrasias.
Regular liver and blood monitoring is recommended, particularly during initiation and dose changes.
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