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Review Details
(4)
| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 133.5MG|58MG |
| Manufacturer | SUN PHARMA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.29 | $ 29.20 |
$ 24.82
Apply ZARVY26 (-15%)
You save $ 4.38
|
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| 2 BOXES - 200 TABLETS | $ 0.22 |
24% $ 58.40
$ 44.10
|
$ 37.49
Apply ZARVY26 (-15%)
You save $ 6.62
|
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.20 |
32% $ 87.60
$ 59.80
|
$ 50.83
Apply ZARVY26 (-15%)
You save $ 8.97
|
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Encorate Chrono 200 is a controlled-release combination tablet containing sodium valproate 133.5mg and valproic acid 58mg, designed to provide steady therapeutic levels of valproate over time. This formulation is commonly used in long-term management of epilepsy and bipolar disorder, particularly when consistent plasma levels are critical for preventing breakthrough seizures or mood destabilization.
- Sleep & Mental Health > Epilepsy This dual-agent formula enhances GABA neurotransmission to stabilize abnormal electrical activity in the brain, effectively managing both generalized and partial seizures. Its extended-release action reduces fluctuations in blood levels, improving compliance and seizure control. > Bipolar Disorder Valproate-based therapies are widely used as mood stabilizers for managing acute mania and preventing recurrence in bipolar I disorder. Encorate Chrono is especially useful when daily consistency is required, often as a monotherapy or in combination with lithium or atypical antipsychotics. > Depression, Anxiety, PTSD Though not a first-line therapy, this medication may provide mood-stabilizing benefits for patients experiencing bipolar-related depression or anxiety symptoms. It is sometimes used adjunctively when conventional antidepressants are insufficient. - Painkillers & Headache > Migraine Prevention Encorate Chrono may also be prescribed to prevent recurrent migraines by modulating cortical excitability and reducing the frequency of attacks. It is especially effective in patients with comorbid seizure or mood disorders.
Sodium valproate and valproic acid increase central GABA levels, which inhibit excessive neuronal firing. The controlled-release mechanism ensures a smooth plasma concentration curve, minimizing peak-trough fluctuations and reducing side effects. This dual formulation helps manage both the neurological and psychiatric dimensions of seizure and mood disorders.
Adult Dosing - Initial: 10–15 mg/kg/day, with food, divided once or twice daily - Titration: Increase by 5–10 mg/kg/week based on response - Maintenance: 20–30 mg/kg/day (typical range: 1200–1800 mg/day) - Max: 60 mg/kg/day (~3600 mg/day for a 60 kg adult) - Notes: Divide doses above 250 mg/day; maintain consistent timing daily Pediatric Dosing (Age 10+) - Initial: 10–15 mg/kg/day with food - Titration: 5–10 mg/kg/week - Max: 60 mg/kg/day - Notes: Monitor liver enzymes and platelets routinely; divide doses >250 mg/day Combination Formulation Considerations - Switching: Start valproate combo as above; taper prior drug by 25% every 2 weeks - Conversion: Do not substitute 1:1 with plain valproic acid/valproate due to kinetic differences - Monitoring: Liver function (AST, ALT), platelet count, ammonia, and plasma valproate levels when clinically indicated
Store in a dry, cool place at temperatures between 15–30°C. Protect from moisture and direct light. Keep container tightly closed and out of reach of children. Avoid humid environments like bathrooms.
- Common: Drowsiness, nausea, tremors, weight gain, menstrual irregularities - Serious: Hepatotoxicity, pancreatitis, thrombocytopenia, encephalopathy - Teratogenicity: Use with caution in women of childbearing age; not recommended during pregnancy unless necessary - Other: Hair thinning, gastrointestinal discomfort - Clinical Monitoring: Liver enzymes and blood counts every 3–6 months during long-term use
My doctor prescribed Encorate Chrono, and this pharmacy provides a consistent supply for my ongoing treatment.
It's a relief to have a dependable online source for my prescription. The service has been flawless.
สั่งยา Encorate Chrono เป็นประจำ บริการดี จัดส่งมาไทยรวดเร็วและแพ็คมาอย่างดีเสมอครับ
For a long-term medication, having a pharmacy that respects my privacy is important. Their discreet shipping is excellent.
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