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| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 333MG|145MG |
| Manufacturer | INTAS PHARMACEUTICALS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 150 TABLETS | $ 0.45 | $ 67.30 |
$ 57.21
Apply ZARVY26 (-15%)
You save $ 10.10
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| 2 BOXES - 300 TABLETS | $ 0.41 |
9% $ 134.60
$ 122.80
|
$ 104.38
Apply ZARVY26 (-15%)
You save $ 18.42
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| ★ Best Value 3 BOXES - 450 TABLETS | $ 0.40 |
10% $ 201.90
$ 181.80
|
$ 154.53
Apply ZARVY26 (-15%)
You save $ 27.27
|
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Valprol CR 500 is an extended-release antiepileptic and mood-stabilizing medication that combines sodium valproate 333mg with valproic acid 145mg. This controlled-release formulation is designed to maintain consistent blood levels, enhancing therapeutic effects while reducing dosing frequency and side effect fluctuations.
- Sleep & Mental Health > Epilepsy This combination treatment promotes GABAergic activity, helping to suppress abnormal neuronal discharges associated with both focal and generalized seizures. Its prolonged-release design ensures consistent therapeutic levels, enhancing long-term seizure management and patient adherence. > Bipolar Disorder Valproic acid derivatives like Encorate Chrono are standard interventions for manic phases and mood stabilization in bipolar I disorder. It is frequently selected for its reliable release profile and can be used alone or with agents like lithium or second-generation antipsychotics. > Depression, Anxiety, PTSD As an off-label option, this formulation supports emotional regulation in cases where antidepressants alone are inadequate. It contributes to stabilizing mood swings, mitigating anxiety-driven symptoms, and controlling behavioral dysregulation common in PTSD. - Painkillers & Headache > Migraine Prevention Encorate Chrono is also utilized prophylactically to reduce the intensity and occurrence of migraines. By dampening cortical overactivity, it offers dual benefit to patients dealing with coexisting neurological or mood conditions.
The dual-action mechanism of sodium valproate and valproic acid enhances GABA activity in the brain. By increasing this inhibitory neurotransmitter, Valprol CR 500 reduces hyperexcitability of neurons, controls seizures, stabilizes emotional fluctuations, and supports neurological balance in conditions like epilepsy and bipolar disorder.
Adult Dosing Guidelines - Initial dose: 10–15 mg/kg/day with or after meals, in 1 or 2 divided doses (e.g., ~600–900 mg/day for a 60 kg adult) - Titration: Increase by 5–10 mg/kg/week based on response and tolerability - Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day) - Maximum dose: Up to 60 mg/kg/day (e.g., 3600 mg/day for a 60 kg adult) - Doses over 250 mg/day should be divided into multiple doses - For once-daily use, take consistently at the same time each day - If seizures persist, monitor plasma levels (target: 50–100 mcg/mL) Pediatric Dosing Guidelines (Ages 10+) - Initial dose: 10–15 mg/kg/day with food, divided if over 250 mg/day (e.g., ~300–450 mg/day for a 30 kg child) - Titration: Increase weekly by 5–10 mg/kg/day based on need - Maintenance/Max dose: Up to 60 mg/kg/day; most stabilize at 20–30 mg/kg/day - Regular monitoring of liver function and platelet count is essential Special Considerations for Combination Formulations - When switching from other antiepileptics: Begin valproate therapy as above while tapering the previous drug by ~25% every 2 weeks Adjust tapering speed based on seizure control and tolerance - Pharmacokinetics: Sodium valproate and valproic acid combination delivers stable serum levels Extended-release formulation allows for once-daily dosing in most cases - Conversion caution: Do not switch 1:1 with non-combination forms due to differing absorption profiles - Monitoring: - Liver enzymes (AST, ALT) - Platelet count - Plasma valproate concentration (if control is inadequate) - Ammonia levels (if signs of hyperammonemia appear)
Store in a cool, dry environment below 25°C. Protect from light and moisture. Keep in original packaging and out of reach of children. Do not freeze.
Common side effects include nausea, dizziness, weight gain, fatigue, tremors, and hair thinning. More serious reactions may involve hepatotoxicity, thrombocytopenia, pancreatitis, and elevated ammonia levels. Regular monitoring is necessary, especially during the initial months of treatment or when combining with other medications.
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