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| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 133.5MG|58MG |
| Manufacturer | INTAS PHARMACEUTICALS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 150 TABLETS | $ 0.24 | $ 35.80 |
$ 30.43
Apply ZARVY26 (-15%)
You save $ 5.37
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| 2 BOXES - 300 TABLETS | $ 0.19 |
19% $ 71.60
$ 57.70
|
$ 49.05
Apply ZARVY26 (-15%)
You save $ 8.66
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| ★ Best Value 3 BOXES - 450 TABLETS | $ 0.18 |
25% $ 107.40
$ 80.90
|
$ 68.77
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You save $ 12.14
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Valprol CR 200 is a controlled-release tablet containing sodium valproate 133.5mg and valproic acid 58mg. This dual-component formulation is designed to maintain consistent plasma drug levels throughout the day, minimizing fluctuations that may cause side effects or breakthrough symptoms. It is commonly used in chronic management of epilepsy and mood stabilization, offering both antiepileptic and mood-regulating benefits.
- Sleep & Mental Health > Epilepsy Valprol CR 200 acts by enhancing GABAergic inhibition in the central nervous system, making it highly effective for treating generalized seizures, partial seizures, and mixed seizure types. Its extended-release mechanism supports more stable control over neuronal excitability and reduces the frequency of dosing. > Bipolar Disorder In bipolar disorder, Valprol CR 200 serves as a cornerstone therapy for acute mania and maintenance treatment. It is particularly useful in preventing mood swings, and is often prescribed either as monotherapy or alongside other agents like lithium or atypical antipsychotics. > Depression, Anxiety, PTSD Valproate-based therapies may be added to antidepressant regimens in treatment-resistant cases, helping to regulate mood instability, impulsivity, and anxiety symptoms. However, its use in this context is supportive and should be closely monitored. - Painkillers & Headache > Migraine Prevention Valprol CR 200 may also be prescribed to prevent recurrent migraines in patients with neurological sensitivity. By stabilizing excitatory brain pathways, it contributes to fewer headache days and reduced severity.
Valprol CR 200 combines sodium valproate and valproic acid to exert broad-spectrum antiepileptic and mood-stabilizing actions. It enhances GABA levels, reduces neuronal hyperexcitability, and modulates synaptic transmission. The controlled-release formulation ensures smoother blood levels, improving tolerability and adherence in long-term therapy.
Adult Dosing - Initial: 10–15 mg/kg/day with or after food, in 1–2 doses - Titration: Increase 5–10 mg/kg/week - Maintenance: 20–30 mg/kg/day (e.g., 1200–1800 mg/day for 60 kg adult) - Max: Up to 60 mg/kg/day (~3600 mg/day) - Notes: Divide doses >250 mg/day; maintain consistent timing; monitor plasma levels if needed Pediatric Dosing (Age 10+) - Initial: 10–15 mg/kg/day with food - Titration: Weekly increments of 5–10 mg/kg/day - Maintenance: Usually 20–30 mg/kg/day - Max: 60 mg/kg/day - Notes: Monitor liver enzymes and platelets regularly; adjust based on seizure type and clinical response Special Considerations - Drug Switch: Taper prior antiepileptic by ~25% every 2 weeks after initiating valproate - Do not use 1:1 substitution with plain valproic acid or sodium valproate - Combination ensures smoother kinetics with longer-lasting effects - Routine Monitoring: AST, ALT, platelet count, plasma valproate level, and ammonia (if symptomatic)
Store in a dry, cool environment below 30°C. Keep away from moisture, direct sunlight, and heat. Ensure tablets remain in original packaging until use. Keep out of reach of children.
- Common: Sleepiness, dizziness, weight gain, hair loss, nausea - Serious: Liver dysfunction, pancreatitis, low platelet count, encephalopathy - Pregnancy: Not recommended unless essential due to teratogenic risk - Other: Polycystic ovary syndrome (PCOS) in females, hormonal disturbances - Monitoring: Regular liver function and blood tests recommended during extended use
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