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Review Details
(6)
| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 266.66MG|116MG |
| Manufacturer | SUN PHARMA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 50 TABLETS | $ 1.18 | $ 58.90 |
$ 50.07
Apply ZARVY26 (-15%)
You save $ 8.84
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| 2 BOXES - 100 TABLETS | $ 1.06 |
10% $ 117.80
$ 105.50
|
$ 89.68
Apply ZARVY26 (-15%)
You save $ 15.83
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| ★ Best Value 3 BOXES - 150 TABLETS | $ 1.03 |
12% $ 176.70
$ 154.90
|
$ 131.67
Apply ZARVY26 (-15%)
You save $ 23.24
|
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Encorate Chrono 400 is a generic extended-release antiepileptic formulation containing sodium valproate (266.66mg) and valproic acid (116mg). This combination is widely prescribed for both neurological and psychiatric conditions due to its dual mechanism of enhancing GABA activity, thereby stabilizing abnormal neuronal firing. Its long-acting nature ensures steady plasma levels, making it particularly suitable for patients who require round-the-clock seizure control or mood stabilization. In addition to managing epilepsy and bipolar disorder, it is often employed as an adjunctive therapy in depression, anxiety, and PTSD when conventional antidepressants fall short. Its preventive effects in chronic migraine management further reinforce its value in neuropsychiatric care. With once-daily dosing potential and broad-spectrum efficacy, Encorate Chrono 400 offers a comprehensive solution for both primary and secondary indications within the mental health spectrum.
- Sleep & Mental Health > Epilepsy This extended-release formulation promotes GABA activity in the central nervous system, helping to suppress irregular neuronal discharges that cause generalized and focal seizures. Its sustained effect ensures consistent therapeutic levels, aiding in better long-term seizure control and adherence. > Bipolar Disorder Valproate-based extended formulations like Encorate Chrono are commonly utilized to manage manic phases and prevent relapses in bipolar I disorder. It serves as a reliable stabilizing option either alone or in combination with agents such as lithium or second-generation antipsychotics. > Depression, Anxiety, PTSD While not typically the first option, this medication can be considered in mood disorders with mood lability or treatment-resistant features. It may be added to standard regimens when emotional regulation is poor or antidepressants alone are inadequate. - Painkillers & Headache > Migraine Prevention Encorate Chrono is also used prophylactically to reduce the incidence and intensity of migraine episodes by influencing neuronal excitability. It is especially beneficial in individuals who also struggle with epilepsy or mood-related comorbidities.
The combination of sodium valproate and valproic acid increases the brain's GABA levels, resulting in a calming effect on excessive electrical activity. This dual-action mechanism helps reduce seizure frequency, stabilize mood fluctuations in bipolar disorder, and dampen the neurological overstimulation associated with chronic migraine, anxiety, and PTSD. Its extended-release formula ensures consistent blood levels and reduces dosing frequency, thereby improving treatment adherence.
Adult Dosing Guidelines - Initial dose: 10–15 mg/kg/day with or after meals, in 1 or 2 divided doses (e.g., ~600–900 mg/day for a 60 kg adult) - Titration: Increase by 5–10 mg/kg/week based on response and tolerability - Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day) - Maximum dose: Up to 60 mg/kg/day (e.g., 3600 mg/day for a 60 kg adult) - Doses over 250 mg/day should be split into multiple doses - For once-daily use, take consistently at the same time each day - If seizures persist, monitor plasma levels (target: 50–100 mcg/mL) Pediatric Dosing Guidelines (Ages 10+) - Initial dose: 10–15 mg/kg/day with meals, divided if over 250 mg/day (e.g., ~300–450 mg/day for a 30 kg child) - Titration: Increase weekly by 5–10 mg/kg/day based on tolerance - Most children stabilize at 20–30 mg/kg/day - Maximum dose: Up to 60 mg/kg/day - Routine monitoring of liver enzymes and platelets is critical Special Considerations for Combination Formulations - When transitioning from other antiepileptics, initiate Encorate Chrono 400 as above - Taper existing medications gradually (~25% reduction every 2 weeks) - Tapering can start immediately or after 1–2 weeks depending on clinical status - The dual formulation provides enhanced bioavailability and more stable serum concentration - Do not substitute 1:1 with standalone valproate or valproic acid due to absorption differences Monitoring Parameters - Liver function (AST, ALT) - Platelet count - Plasma ammonia (if altered mental status or lethargy) - Valproate serum levels (in cases of poor control or suspected toxicity)
Store in a dry, cool location between 20–25°C. Keep away from direct sunlight, heat, and moisture. Store tablets in the original container and ensure they are inaccessible to children.
Common side effects include dizziness, nausea, tremor, increased appetite, and hair thinning. More serious but less frequent reactions may involve liver dysfunction, pancreatitis, thrombocytopenia, and hyperammonemic encephalopathy. Liver enzymes and platelet counts should be checked periodically. In rare cases, cognitive dulling and sedation may occur, especially at higher doses.
The 400mg dose of Encorate Chrono has been working well for my stability. This pharmacy is my trusted source for refills.
Уже несколько раз заказывал Энкорат Хроно 400мг. Доставка всегда вовремя, качество на высоте.
I've been a customer for many months, and they've never let me down. Consistently professional and reliable service.
It's a huge relief to have a pharmacy that ships my Encorate Chrono to Canada so reliably. Their service is top-notch.
I appreciate that their website makes managing my long-term prescription so simple and quick. The UI is excellent.
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