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Review Details
(5)
| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 333MG|145MG |
| Manufacturer | SUN PHARMA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.51 | $ 50.50 |
$ 42.93
Apply ZARVY26 (-15%)
You save $ 7.58
|
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| 2 BOXES - 200 TABLETS | $ 0.44 |
13% $ 101.00
$ 88.10
|
$ 74.88
Apply ZARVY26 (-15%)
You save $ 13.22
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.43 |
16% $ 151.50
$ 128.00
|
$ 108.80
Apply ZARVY26 (-15%)
You save $ 19.20
|
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Encorate Chrono 500 is a generic extended-release antiepileptic medication that combines sodium valproate 333mg with valproic acid 145mg. This dual-component formulation allows for controlled plasma concentration, enabling more consistent seizure control and mood stabilization throughout the day.
- Sleep & Mental Health > Epilepsy Encorate Chrono 500 is frequently recommended as a foundational treatment for managing both generalized and focal (partial) seizures. By boosting gamma-aminobutyric acid (GABA) activity in the central nervous system, it helps calm hyperactive neurons and reduce seizure episodes. It is especially effective in long-term seizure control for individuals newly diagnosed or experiencing inadequate response to prior medications. > Bipolar Disorder This medication plays a central role in stabilizing mood in patients with bipolar disorder. It is often prescribed to control acute manic or hypomanic states and is routinely used for maintenance therapy to prevent relapses. In cases where lithium is not tolerated or effective, Encorate Chrono 500 provides a reliable alternative with mood-stabilizing effects. > Depression, Anxiety, PTSD In complex psychiatric cases involving emotional dysregulation, impulsivity, or residual anxiety, Encorate Chrono 500 is occasionally added to existing regimens. Its neurochemical action helps mitigate mood swings and emotional overactivation, contributing to improved outcomes in disorders like PTSD and treatment-resistant depression. Painkillers & Headache > Migraine Prevention Encorate Chrono 500 has been recognized for its preventive benefits in chronic and recurrent migraines. By modulating neuronal excitability and stabilizing cortical pathways, it decreases the likelihood and intensity of migraine attacks, especially in patients who have not found relief with conventional analgesics or triptans.
The synergistic action of sodium valproate and valproic acid increases the brain’s GABA levels, an inhibitory neurotransmitter. By calming excessive neural activity, the formulation helps suppress epileptic seizures, improves emotional regulation, and reduces the recurrence of mood disturbances.
Adult Dosing Guidelines - Initial dose: 10–15 mg/kg/day with or after meals, in 1 or 2 divided doses (e.g., ~600–900 mg/day for a 60 kg adult) - Titration: Increase by 5–10 mg/kg/week based on response and tolerability - Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day) - Maximum dose: Up to 60 mg/kg/day (e.g., 3600 mg/day for a 60 kg adult) - Doses over 250 mg/day should be split into multiple doses - For once-daily use, take consistently at the same time each day - If seizures persist, monitor plasma levels (target: 50–100 mcg/mL) Pediatric Dosing Guidelines (Ages 10+) - Initial dose: 10–15 mg/kg/day with food, divided if over 250 mg/day (e.g., ~300–450 mg/day for a 30 kg child) - Titration: Increase weekly by 5–10 mg/kg/day as needed - Maintenance/Max dose: Up to 60 mg/kg/day, though most children stabilize at 20–30 mg/kg/day - Routine monitoring of liver function and platelet count is essential Special Considerations for Combination Formulations - When switching from other antiepileptics: Start valproate combination therapy as above Gradually taper the previous drug by ~25% every 2 weeks Tapering may begin immediately or after a short delay based on clinical need - Pharmacokinetics: Sodium valproate + valproic acid provide stable drug levels Extended-release enables once-daily dosing in most patients - Conversion caution: Do not substitute 1:1 with monotherapy forms due to absorption differences - Monitoring parameters: - Liver enzymes (AST, ALT) - Platelet count - Ammonia levels (if clinical suspicion of hyperammonemia) - Plasma valproate concentration (in treatment-resistant cases)
Store at room temperature below 25°C, in a dry place away from direct sunlight and humidity. Keep the blister packaging intact until use and out of reach of children.
Common side effects include gastrointestinal upset, weight gain, fatigue, hair thinning, and mild tremors. Serious adverse effects can involve hepatic dysfunction, pancreatitis, blood dyscrasias (e.g., thrombocytopenia), and hyperammonemia, especially with long-term use. Liver function and blood counts should be regularly monitored to prevent complications.
I've been on 500mg of Encorate Chrono for a while. This pharmacy is the only place I trust for my long-term prescription needs.
I love how easy it is to reorder my prescription. The user experience is clean, simple, and respects my time.
For anyone in Canada on a long-term medication, this service is a lifesaver. Reliable, fast, and professional every single time.
This medication has been a key part of my stability. So grateful for this pharmacy's consistently professional and reliable service.
Month after month, they deliver. Their professionalism and commitment to privacy are why I'm a loyal customer.
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