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| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 266.66MG|116MG |
| Manufacturer | INTAS PHARMACEUTICALS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 150 TABLETS | $ 0.64 | $ 95.70 |
$ 81.35
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| 2 BOXES - 300 TABLETS | $ 0.61 |
5% $ 191.40
$ 181.50
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$ 154.28
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| ★ Best Value 3 BOXES - 450 TABLETS | $ 0.61 |
5% $ 287.10
$ 272.60
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$ 231.71
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Valprol CR 400 is a generic extended-release antiepileptic medication combining sodium valproate 266.66mg and valproic acid 116mg. It is designed to provide consistent plasma levels over 24 hours, making it suitable for long-term management of neurological and psychiatric disorders.
- Sleep & Mental Health > Epilepsy By enhancing gamma-aminobutyric acid (GABA) transmission, this medication suppresses excessive neuronal firing responsible for generalized and localized seizures. Its controlled-release profile allows for smoother blood concentration levels, improving efficacy and minimizing dose-related side effects. > Bipolar Disorder Frequently prescribed for both acute mania and long-term stabilization, valproate-based formulations like Encorate Chrono help regulate mood cycles. It is often chosen for patients who require dependable dosing and may be combined with mood-stabilizing agents such as lithium or quetiapine. > Depression, Anxiety, PTSD Though considered an off-label approach, this drug is sometimes used in patients whose mood disorders include impulsivity or emotional instability. It can be added to primary treatments when conventional antidepressants do not provide sufficient relief. - Painkillers & Headache > Migraine Prevention Encorate Chrono also serves as a preventive therapy for migraines by dampening cortical hyperexcitability. Its use is especially valuable for individuals with overlapping neurological or psychiatric disorders where dual benefit is needed.
The combination of sodium valproate and valproic acid enhances GABA neurotransmission, which suppresses abnormal brain activity. This dual mechanism provides effective control over seizures and contributes to mood stabilization in bipolar disorder.
Adult Dosing Guidelines - Initial dose: 10–15 mg/kg/day with or after meals, in 1 or 2 divided doses (e.g., ~600–900 mg/day for a 60 kg adult) - Titration: Increase by 5–10 mg/kg/week based on response and tolerability - Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day) - Maximum dose: Up to 60 mg/kg/day (e.g., 3600 mg/day for a 60 kg adult) - Doses over 250 mg/day should be divided - For once-daily use, take consistently at the same time daily - If seizures persist, monitor plasma levels (target: 50–100 mcg/mL) Pediatric Dosing Guidelines (Ages 10+) - Initial dose: 10–15 mg/kg/day with meals, divided if over 250 mg/day (e.g., ~300–450 mg/day for a 30 kg child) - Titration: Increase weekly by 5–10 mg/kg/day as needed - Maintenance/Max dose: Up to 60 mg/kg/day - Most children stabilize at 20–30 mg/kg/day - Routine monitoring of liver enzymes and platelet count is critical Special Considerations for Combination Formulations - When switching from other antiepileptics: Begin valproate combination therapy as above Gradually taper the previous drug by ~25% every 2 weeks Delay or initiate tapering immediately based on clinical response - Pharmacokinetics: The dual formulation supports consistent blood levels and allows for once-daily dosing - Conversion caution: Do not substitute directly with single-ingredient sodium valproate or valproic acid - Monitoring: - Liver enzymes (AST, ALT) - Platelet count - Ammonia (if symptomatic) - Plasma valproate levels (for poor responders)
Store in a cool, dry place below 25°C. Keep away from direct sunlight and moisture. Ensure the tablets are kept in their original packaging and out of reach of children.
Common side effects may include nausea, weight gain, tremor, and drowsiness. Some patients may experience hair thinning or mild digestive upset. Serious but less common effects include liver toxicity, pancreatitis, thrombocytopenia, and signs of hyperammonemia (e.g., confusion, vomiting). Immediate medical attention is required if these occur.
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