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| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 200MG|87MG |
| Manufacturer | MICRO LABS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.50 | $ 49.60 |
$ 42.16
Apply ZARVY26 (-15%)
You save $ 7.44
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| 2 BOXES - 200 TABLETS | $ 0.43 |
13% $ 99.20
$ 86.20
|
$ 73.27
Apply ZARVY26 (-15%)
You save $ 12.93
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.42 |
16% $ 148.80
$ 125.10
|
$ 106.34
Apply ZARVY26 (-15%)
You save $ 18.77
|
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Valprid CR 300 is a generic extended-release formulation that combines sodium valproate and valproic acid. It is primarily used to treat epilepsy and bipolar disorder, functioning by enhancing the action of GABA, the brain's inhibitory neurotransmitter. This helps regulate abnormal electrical activity in the brain. In psychiatric settings, it serves as a mood stabilizer in patients with mood swings, depression, or PTSD. Its extended-release properties offer steady plasma concentrations, enabling more predictable therapeutic effects with once-daily dosing.
Sleep & Mental Health > Epilepsy Valprid CR 300 is frequently recommended as a foundational treatment for managing both generalized and focal (partial) seizures. By boosting gamma-aminobutyric acid (GABA) activity in the central nervous system, it helps calm hyperactive neurons and reduce seizure episodes. It is especially effective in long-term seizure control for individuals newly diagnosed or experiencing inadequate response to prior medications. > Bipolar Disorder This medication plays a central role in stabilizing mood in patients with bipolar disorder. It is often prescribed to control acute manic or hypomanic states and is routinely used for maintenance therapy to prevent relapses. In cases where lithium is not tolerated or effective, Valprol CR 300 provides a reliable alternative with mood-stabilizing effects. > Depression, Anxiety, PTSD In complex psychiatric cases involving emotional dysregulation, impulsivity, or residual anxiety, Valprid CR 300 is occasionally added to existing regimens. Its neurochemical action helps mitigate mood swings and emotional overactivation, contributing to improved outcomes in disorders like PTSD and treatment-resistant depression. Painkillers & Headache > Migraine Prevention Valprid CR 300 has been recognized for its preventive benefits in chronic and recurrent migraines. By modulating neuronal excitability and stabilizing cortical pathways, it decreases the likelihood and intensity of migraine attacks, especially in patients who have not found relief with conventional analgesics or triptans.
Valproate and valproic acid work by increasing GABA concentrations in the central nervous system, which calms hyperactive nerve signaling. This reduces the frequency of seizures, stabilizes mood, and decreases migraine episodes. The combination formulation enhances therapeutic coverage through balanced bioavailability.
Adult Dosing Guidelines - Initial dose: 10–15 mg/kg/day with or after meals, in 1 or 2 divided doses (e.g., ~600–900 mg/day for a 60 kg adult) - Titration: Increase by 5–10 mg/kg/week based on clinical response - Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day) - Maximum dose: Up to 60 mg/kg/day (e.g., 3600 mg/day for a 60 kg adult) - Doses exceeding 250 mg/day should be split into two or more doses - Take at the same time each day to ensure steady plasma levels - If seizures persist, monitor plasma levels (target: 50–100 mcg/mL) Pediatric Dosing Guidelines (Ages 10+) - Initial dose: 10–15 mg/kg/day with food, divided if over 250 mg/day (e.g., ~300–450 mg/day for a 30 kg child) - Titration: Weekly increments of 5–10 mg/kg/day if tolerated - Most children stabilize at 20–30 mg/kg/day; max 60 mg/kg/day - Liver function and platelet count monitoring is essential Combination Formulation Notes - When switching from other antiepileptics, initiate valproate as above - Taper the existing drug by ~25% every two weeks - Tapering can start immediately or after 1–2 weeks depending on clinical need - The dual-component formulation enables extended serum coverage - Do not substitute 1:1 with single-component valproic acid or sodium valproate due to absorption differences Monitoring Recommendations - Liver function tests (AST, ALT) - Platelet count - Ammonia levels if encephalopathy is suspected - Plasma valproate levels in poor responders
Store in a cool, dry place between 20–25°C, away from direct sunlight and humidity. Keep the tablets in their original container and out of reach of children.
Common side effects include nausea, tremor, weight gain, hair thinning, and drowsiness. Rare but serious adverse events may include liver toxicity, pancreatitis, thrombocytopenia, and elevated blood ammonia levels. Regular blood tests are recommended during long-term therapy.
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