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| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 333MG|145MG |
| Manufacturer | MICRO LABS |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.50 | $ 49.90 |
$ 42.42
Apply ZARVY26 (-15%)
You save $ 7.49
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| 2 BOXES - 200 TABLETS | $ 0.43 |
13% $ 99.80
$ 86.90
|
$ 73.87
Apply ZARVY26 (-15%)
You save $ 13.04
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.42 |
16% $ 149.70
$ 126.20
|
$ 107.27
Apply ZARVY26 (-15%)
You save $ 18.93
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Valprid CR 500 is a controlled-release anticonvulsant and mood stabilizer that combines sodium valproate 333mg and valproic acid 145mg. It is designed to deliver consistent therapeutic effects over extended periods, helping stabilize brain activity and reduce the frequency of seizures and mood fluctuations.
Epilepsy
By boosting inhibitory GABA signals, this dual-formulation suppresses abnormal brain firing patterns, effectively controlling both generalized and focal seizures. Its controlled-release mechanism supports stable plasma concentrations and improves overall treatment consistency.
Bipolar Disorder
Encorate Chrono is a widely trusted choice for acute mania and long-term stabilization in bipolar I disorder. Its gradual release makes it ideal for daily use, either as a standalone therapy or in combination with lithium or atypical antipsychotics.
Depression, Anxiety, PTSD
While not a frontline treatment, it is occasionally prescribed in complex psychiatric cases to reinforce mood balance and reduce heightened emotional responses. It provides therapeutic value when standard antidepressants fail to deliver sufficient results.
Migraine Prevention
Encorate Chrono also serves as a preventive therapy in migraine-prone individuals by minimizing neural overactivity. It is particularly useful for patients who experience migraines alongside seizure disorders or mood-related conditions.
The combination of sodium valproate and valproic acid increases the brain’s GABA levels, suppressing abnormal neuronal activity. This leads to a reduction in seizure occurrence, improved mood stabilization, and potential support for co-occurring symptoms such as anxiety and agitation.
Adult Dosing Guidelines
Initial dose: 10–15 mg/kg/day with or after meals, in 1 or 2 divided doses (approximately 600–900 mg/day for a 60 kg adult).
Titration: Increase by 5–10 mg/kg/week based on response and tolerability.
Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day).
Maximum dose: Up to 60 mg/kg/day (around 3600 mg/day for a 60 kg adult).
Doses over 250 mg/day should be divided into multiple doses.
For once-daily use, take consistently at the same time each day.
If seizures persist, monitor plasma levels (target range: 50–100 mcg/mL).
Pediatric Dosing Guidelines (Ages 10+)
Initial dose: 10–15 mg/kg/day with meals, divided if over 250 mg/day (approximately 300–450 mg/day for a 30 kg child).
Titration: Increase weekly by 5–10 mg/kg/day based on tolerance.
Most children stabilize at 20–30 mg/kg/day.
Maximum dose: Up to 60 mg/kg/day.
Routine monitoring of liver enzymes and platelets is essential.
Special Considerations for Combination Formulations
When switching from other antiepileptics:
Start valproate combination therapy as above, and gradually taper the prior drug by ~25% every 2 weeks. Adjust based on seizure control and side effect profile.
Pharmacokinetics:
Provides stable serum levels through its extended-release profile, allowing for once-daily dosing in most patients.
Conversion caution:
Do not switch 1:1 with single-ingredient formulations.
Monitoring parameters:
Liver enzymes (AST, ALT)
Platelet count
Plasma valproate level
Ammonia (if hyperammonemia is suspected)
Store in a dry, cool place below 25°C. Protect from light and moisture. Keep the tablets in their original packaging and out of reach of children.
Common side effects include gastrointestinal upset, fatigue, tremors, and weight gain. More serious risks include liver toxicity, pancreatitis, low platelet count, and elevated ammonia levels. Regular blood monitoring is strongly advised during long-term use.
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