Exchange & Returns Information
Review Details
(0)
| Generic For | N/A |
|---|---|
| Active Ingredient | SODIUM VALPROATE|VALPROIC ACID |
| Strength | 200MG|87MG |
| Manufacturer | INTAS PHARMACEUTICALS LTD |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.50 | $ 49.60 |
$ 42.16
Apply ZARVY26 (-15%)
You save $ 7.44
|
||
| 2 BOXES - 200 TABLETS | $ 0.43 |
13% $ 99.20
$ 86.20
|
$ 73.27
Apply ZARVY26 (-15%)
You save $ 12.93
|
||
| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.42 |
16% $ 148.80
$ 125.10
|
$ 106.34
Apply ZARVY26 (-15%)
You save $ 18.77
|
Reference information will be available soon.
Valprol CR 300 is a controlled-release formulation that combines sodium valproate 200mg and valproic acid 87mg, designed for consistent therapeutic blood levels. This combination enhances GABAergic activity in the brain, providing a stabilizing effect for various neurological and psychiatric conditions. The CR (controlled release) profile ensures a steady plasma concentration, reducing dosing frequency and improving compliance, especially for patients needing long-term therapy.
Sleep & Mental Health > Epilepsy Valprol CR 300 effectively manages generalized and partial seizures by modulating neuronal excitability through increased GABA availability. It is commonly prescribed as a first-line antiepileptic in both newly diagnosed and treatment-resistant cases. > Bipolar Disorder Valprol CR 300 is also widely used for the acute treatment of manic episodes and for maintenance therapy in bipolar disorder. It serves as a mood stabilizer, helping to prevent mood fluctuations and often complements or replaces lithium in clinical settings. > Depression, Anxiety, PTSD In patients with mood instability or treatment-resistant depression and anxiety, Valprol CR 300 may be used off-label as an adjunctive therapy. It assists in reducing impulsivity, emotional dysregulation, and intrusive symptoms often seen in PTSD. Painkillers & Headache > Migraine Prevention Valprol CR 300 helps reduce the frequency and severity of migraines by normalizing cortical excitability. Its prophylactic use is well-supported in patients with chronic or episodic migraines, especially those unresponsive to typical analgesics.
Valprol CR 300 increases synaptic GABA levels, an inhibitory neurotransmitter, by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase. It also modulates sodium and calcium channels, stabilizing neuronal membranes. This dual mechanism provides broad-spectrum anticonvulsant activity and mood-stabilizing effects. The presence of both sodium valproate and valproic acid enhances absorption and maintains more stable drug levels throughout the dosing period.
Adult Dosing Guidelines - Initial dose: 10–15 mg/kg/day (e.g., 600–900 mg/day for 60 kg adult), taken with or after meals - Titration: Increase by 5–10 mg/kg/week based on therapeutic response and side effect profile - Maintenance dose: 20–30 mg/kg/day (typically 1200–1800 mg/day) - Maximum dose: Up to 60 mg/kg/day (e.g., 3600 mg/day for 60 kg adult) Important notes: - Doses exceeding 250 mg/day should be divided - Once-daily regimens should be taken at the same time each day - Plasma valproate levels should be monitored if seizures persist (target range: 50–100 mcg/mL) Pediatric Dosing Guidelines (Ages 10+) - Initial dose: 10–15 mg/kg/day, divided if over 250 mg/day (e.g., ~300–450 mg/day for a 30 kg child) - Titration: 5–10 mg/kg/day weekly increases as tolerated - Maintenance/Max dose: Most stabilize at 20–30 mg/kg/day; max is 60 mg/kg/day Important notes: - Liver enzymes and platelet count must be regularly monitored - Adjust dose based on seizure complexity and individual response - Tapering should be slow to prevent seizure recurrence Special Considerations for Combination Formulations - When switching from other antiepileptics, initiate Valprol CR 300 per above dosing and taper the previous drug by ~25% every 2 weeks - Delay in tapering may be considered depending on clinical need - Do not substitute with single-agent formulations due to altered bioavailability - Once-daily dosing supported by extended-release profile Monitoring recommendations: - Liver function (AST, ALT) - Platelet count - Ammonia levels (if signs of confusion, vomiting, or lethargy occur) - Plasma valproate concentrations in case of poor seizure or mood control
Store Valprol CR 300 below 30°C in a dry, cool location away from direct sunlight. Keep the medication in its original blister packaging. Ensure it is kept out of reach of children and do not use tablets that are chipped or discolored.
Common side effects include mild gastrointestinal discomfort (nausea, indigestion), drowsiness, dizziness, weight gain, and tremor. Serious adverse reactions may include hepatotoxicity, pancreatitis, thrombocytopenia, and hyperammonemic encephalopathy. Psychiatric symptoms such as mood swings or irritability may also emerge in sensitive individuals. Long-term users should receive periodic liver function tests, blood counts, and serum valproate monitoring.
No reviews yet. Be the first to review this product!
No combo deals available at the moment.
