Innomer 500, Meropenem, Antibiotics & Infections, Online Pharmacy, ZarvyPharm
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ANTIBIOTICS Sepsis Klebsiella pneumoniae CRE infections Systemic Infection Meningitis

Innomer 500, Solution For Injection

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Generic For MERREM I.V.
Active Ingredient MEROPENEM
Strength 500MG
Manufacturer BDR PHARMA
Innomer 500 injection box, front view with readable label
Innomer 500 vial next to product box, packaging close-up
Innomer 500 injection 2 boxes, front view with readable label
Innomer 500 injection box, front view with readable label
Innomer 500 vial next to product box, packaging close-up
Innomer 500 injection 2 boxes, front view with readable label
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Product Description

Innomer 500, Solution for Injection contains meropenem, a potent broad-spectrum carbapenem antibiotic highly resistant to β-lactamase degradation. It demonstrates powerful activity against Gram-positive, Gram-negative, and anaerobic bacteria, making it indispensable for treating severe and life-threatening infections.
Meropenem rapidly kills bacteria by inhibiting cell wall synthesis through high-affinity binding to penicillin-binding proteins (PBPs).

Its resistance to most β-lactamases, including ESBLs and AmpC, together with excellent tissue penetration, makes it invaluable in ICU settings and systemic infection management.
It is widely indicated in sepsis, meningitis, intraabdominal infections, pneumonia, and multidrug-resistant cases such as ESBL-producing Klebsiella pneumoniae.

Available through a trusted online pharmacy, it is a frontline choice in the Antibiotics & Infections category, often considered alongside agents like Zithromax, Vibramycin, or Novamox depending on the clinical scenario.

Indications & Uses

  • Systemic Infections: Empiric or targeted therapy for severe, polymicrobial, or MDR infections.
  • Sepsis: Core treatment in septicemia protocols, often combined with other agents.
  • Meningitis: Preferred carbapenem for bacterial meningitis due to reliable CNS penetration.
  • Klebsiella pneumoniae: Effective against ESBL and MDR strains; used in high-risk cases.
  • CRE Infections: Utilized in salvage or combination therapy when isolates remain susceptible.

Benefits & Effectiveness

  • Rapid bactericidal activity by inhibiting bacterial cell wall synthesis.
  • Broad-spectrum coverage including most aerobic and anaerobic Gram-negative rods.
  • Resistant to hydrolysis by most β-lactamases, including ESBLs.
  • High efficacy in CNS infections due to favorable pharmacokinetics.
  • Lower seizure risk than imipenem, making Innomer (meropenem) suitable for CNS indications.

Directions for Use

  • Skin & Structure Infections: Adults 500 mg IV every 8h; severe Pseudomonas – 1 g IV every 8h. Pediatrics ≥3 months – 10 mg/kg IV every 8h (max 500 mg/dose).
  • Intra-abdominal Infections: Adults 1 g IV every 8h. Pediatrics <3 months – 20–30 mg/kg IV every 8–12h; ≥3 months – 20 mg/kg IV every 8h (max 1 g/dose).
  • Meningitis: Adults 2 g IV every 8h for 7–21 days. Pediatrics ≥3 months – 40 mg/kg IV every 8h (max 2 g/dose).
  • Nosocomial Pneumonia: Adults 1 g IV every 8h for 7–14 days (shorter if non-Pseudomonas). Pediatrics dosed as for skin/structure infections.
  • Duration and combination therapy should follow local guidelines and susceptibility testing.

Storage

  • Store unopened vials below 25 °C, protected from moisture and light. Keep vials in the original carton to shield from direct exposure and maintain stability until the labeled expiry date.
  • Reconstituted solutions should be prepared under aseptic conditions and used immediately whenever possible. If storage is necessary, follow manufacturer-recommended stability data and institutional pharmacy guidelines for beyond-use dating.
  • Do not freeze reconstituted or diluted solutions, as freezing may compromise drug potency or stability. Discard any unused solution once recommended stability limits are exceeded.
  • Keep all vials and prepared solutions out of reach of children and ensure handling is restricted to qualified healthcare professionals.

Possible Side Effects

  • Common: nausea, diarrhea, headache, rash, and injection-site inflammation; these are usually mild and manageable during therapy with Innomer (meropenem).
  • Moderate: thrombocytosis, elevated liver enzymes, or anemia; monitor complete blood count and liver function tests during prolonged use.
  • Serious: hypersensitivity reactions, Clostridioides difficile–associated colitis, seizures (especially in patients with renal impairment or preexisting CNS disorders), and anaphylaxis. Immediate medical attention is required for severe events, and discontinuation of Innomer 500/1000 should be considered.

FAQs

Cross-reactivity is low, but caution is advised; perform allergy assessment before use.
Yes, dosing frequency and amount must be reduced in patients with decreased creatinine clearance.
Yes, but combination therapy may be preferred in suspected polymicrobial or MDR infections.
No, MRSA is intrinsically resistant; add anti-MRSA agents if suspected.
Clinical improvement is often seen within 24–48 hours in responsive infections, though full treatment courses must be completed.

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