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| Generic For | SPORANOX |
|---|---|
| Active Ingredient | ITRACONAZOLE |
| Strength | 200MG |
| Manufacturer | GLENMARK |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 30 CAPSULES | $ 1.16 | $ 34.90 |
$ 29.67
Apply ZARVY26 (-15%)
You save $ 5.24
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| 2 BOXES - 60 CAPSULES | $ 1.20 | $ 71.90 |
$ 61.12
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You save $ 10.79
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| ★ Best Value 3 BOXES - 90 CAPSULES | $ 1.19 | $ 106.90 |
$ 90.87
Apply ZARVY26 (-15%)
You save $ 16.04
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Syntran 200 contains Itraconazole 200mg, a systemic triazole antifungal medication designed to treat a wide array of fungal infections affecting both superficial and deep tissues. By selectively inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, itraconazole disrupts the production of ergosterol, a crucial component of fungal cell membranes. This disruption results in increased membrane permeability, cellular leakage, and eventual fungal cell death. With high oral bioavailability and prolonged tissue retention—especially in skin, nails, lungs, and mucosal surfaces—itraconazole is regarded as one of the most versatile antifungals in clinical use. It is recommended for both curative and prophylactic applications, particularly in immunocompromised patients vulnerable to opportunistic fungal pathogens.
• Antibiotics & Infections > Vaginal & Oral Candidiasis
Effectively manages recurrent vulvovaginal candidiasis and oral thrush in patients unresponsive to topical antifungals. Reduces discharge, irritation, and mucosal lesions through short-course systemic therapy.
• Antibiotics & Infections > Tinea Versicolor & Dermatophytosis
Indicated for tinea infections such as corporis, cruris, pedis, and versicolor. Especially useful in widespread or refractory cases where topical agents provide insufficient coverage.
• Antibiotics & Infections > Fungal Keratitis
Administered in combination with antifungal eye drops for deep corneal infections. Helps restore corneal clarity, reduce inflammation, and improve visual acuity in fungal keratitis.
• Antibiotics & Infections > Onychomycosis
Penetrates deep into keratinized tissues to treat both fingernail and toenail fungal infections. Demonstrates high cure rates through pulse or continuous dosing, with excellent nail bed retention.
• Antibiotics & Infections > Systemic Fungal Infections
Recommended for invasive mycoses including aspergillosis, histoplasmosis, cryptococcosis (including meningitis), and other systemic fungal infections. Serves as either a primary or step-down therapy.
• Antibiotics & Infections > Prophylactic Use in Immunocompromised Patients
Prevents fungal infections in individuals with weakened immunity due to chemotherapy, organ transplantation, or long-term corticosteroid use. Reduces morbidity and mortality in high-risk populations.
Key Benefits / Mechanism
Itraconazole impairs fungal cell membrane synthesis by inhibiting ergosterol production. This disruption leads to irreversible damage in fungal cells, limiting their ability to grow and replicate.
Its strong affinity for lipophilic and keratin-rich tissues allows sustained drug release, making it highly effective for long-term treatment of chronic fungal infections. Unlike older azoles, itraconazole demonstrates a broad spectrum of action against both yeasts and molds, covering a wide range of superficial and systemic fungal pathogens.
It is especially effective in regions with high fungal burden and is recognized for its favorable safety profile when administered with appropriate hepatic and cardiac monitoring. The 200mg formulation provides convenient once-daily dosing for many indications, enhancing patient adherence and reducing pill burden in long-term regimens.
Dosage & Administration
Adults
• Blastomycosis: 200 mg three times daily for 3 days, then 200 mg once daily (Max: 400 mg/day). Severe or CNS forms: 200 mg twice–three times daily for ≥12 months following IV amphotericin B.
• Histoplasmosis: 200 mg three times daily for 3 days, then 200 mg once–twice daily. Acute: 6–12 weeks; disseminated: ≥12 months; CNS: continue until CSF normalization.
• Aspergillosis: 200 mg three times daily for 3 days, then 200 mg twice daily. Used as salvage or primary therapy for ABPA and invasive aspergillosis.
• Oral Thrush: 200 mg once daily for 1–2 weeks; refractory: 100 mg twice daily.
• Esophageal Candidiasis: 100–200 mg once daily for ≥3 weeks and continue at least 2 weeks beyond symptom resolution.
• Onychomycosis: Toenails – 200 mg once daily for 12 weeks; Fingernails – 200 mg twice daily for 1 week, repeated after 3 weeks, for 2 cycles.
• Coccidioidomycosis: 200 mg twice daily; CNS cases may require up to four times daily lifelong.
• Sporotrichosis: Cutaneous – 200 mg once daily for 3–6 months; Disseminated/CNS – 200 mg twice daily for ≥12 months.
• Cryptococcosis (non-CNS): 200 mg twice daily for 6–12 months.
• Cryptococcal Meningitis: 200 mg twice daily for ≥8 weeks (consolidation therapy).
• Vaginal Candidiasis: 200 mg once daily for 3–7 days.
• Microsporidiosis: 400 mg once daily; combine with albendazole for disseminated disease.
• Paracoccidioidomycosis: 200 mg once daily for 9–18 months.
Pediatrics
• Blastomycosis: 10 mg/kg once daily for 6–12 months (Max: 400 mg/day); severe cases: same dose after IV amphotericin B.
• Histoplasmosis: 5–10 mg/kg/day divided twice daily; prophylaxis: 5 mg/kg once daily (Max: 200 mg/day).
• HIV-Positive Children: 2–5 mg/kg three times daily × 3 days, then twice daily for 12 months (Max: 200 mg/dose).
• Secondary Prophylaxis: 5–10 mg/kg once daily.
• Oral Thrush: 2.5 mg/kg twice daily for 7–14 days (Max: 400 mg/day); adolescents: 200 mg once daily.
• Esophageal Candidiasis: Children – 2.5 mg/kg twice daily ≥3 weeks + 2 weeks beyond symptom resolution; Adolescents – 200 mg once daily for 14–21 days.
• Coccidioidomycosis: Children – 2–5 mg/kg three times daily × 3 days, then twice daily (Max: 200 mg/dose); Adolescents – 200 mg twice–three times daily.
• Cryptococcosis: Children – 5 mg/kg once daily ≥1 year (Max: 200 mg/dose); CNS – loading 2.5–5 mg/kg three times daily × 3 days, then 5–10 mg/kg once daily.
• Vaginal Candidiasis: 200 mg once daily for 3–7 days (adolescents).
• Microsporidiosis: 400 mg once daily (adolescents) combined with albendazole.
• Sporotrichosis: 6–10 mg/kg once daily (Max: 400 mg/day); disseminated cases follow the same protocol.
Administration Guidance
Take immediately after a full meal to optimize absorption. Avoid concurrent use with antacids or acid-suppressing drugs unless separated by several hours. If a dose is missed, take promptly unless close to the next dose; do not double doses. Regular liver function tests are advised for long-term therapy. Use with caution in patients with cardiac history or ventricular dysfunction; monitor for signs of heart failure.
Store in a dry, cool location below 25°C.
Protect from direct light and excessive humidity.
Keep capsules sealed in their original container until use.
Always close the cap tightly after opening.
Keep out of reach of children.
Common: nausea, headache, abdominal discomfort, dizziness, and mild rash.
Serious: hepatotoxicity, congestive heart failure, QT prolongation, and hypokalemia.
Rare but critical: Stevens-Johnson syndrome and anaphylaxis have been reported.
Monitoring: liver enzymes and cardiac function should be periodically assessed during prolonged therapy.
Precaution: discontinue use and seek immediate care if signs of liver damage, allergic skin reaction, or irregular heartbeat develop.
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