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| Generic For | SPORANOX |
|---|---|
| Active Ingredient | ITRACONAZOLE |
| Strength | 100MG |
| Manufacturer | OAKNET HEALTHCARE |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 CAPSULES | $ 0.75 | $ 74.90 |
$ 63.67
Apply ZARVY26 (-15%)
You save $ 11.24
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| 2 BOXES - 200 CAPSULES | $ 0.73 |
2% $ 149.80
$ 146.90
|
$ 124.87
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You save $ 22.04
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| ★ Best Value 3 BOXES - 300 CAPSULES | $ 0.72 |
3% $ 224.70
$ 216.90
|
$ 184.37
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You save $ 32.54
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Flucos Itz 100 contains Itraconazole 100mg, a systemic triazole antifungal that interferes with fungal cell membrane synthesis by inhibiting lanosterol 14-α-demethylase. This disruption leads to defective cell membranes and inhibition of fungal growth.
Known for its broad-spectrum activity, itraconazole is effective against both superficial and deep fungal infections caused by Candida, Aspergillus, Cryptococcus, and various endemic fungi. Its lipophilic nature ensures strong penetration into keratin-rich tissues such as skin and nails, and sustained concentrations in lungs and mucosal tissues.
It is frequently prescribed for chronic or recurrent mycoses and is included in multiple international guidelines as a first-line or step-down therapy, particularly in immunocompromised hosts.
Antibiotics & Infections > Vaginal & Oral Candidiasis
Used for treatment of persistent or recurrent vulvovaginal candidiasis and oral thrush. Especially effective in cases unresponsive to topical antifungal therapy, providing systemic clearance and symptom relief including discharge, irritation, and oral plaques.
• Antibiotics & Infections > Tinea Versicolor & Dermatophytosis
Indicated for fungal skin conditions such as tinea corporis, cruris, pedis, and versicolor. Offers improved adherence and broader efficacy compared to topical creams due to deep tissue distribution.
• Antibiotics & Infections > Fungal Keratitis
Effective when used in combination with topical agents for treating fungal corneal infections. Helps reduce inflammation, restore visual clarity, and alleviate pain caused by filamentous fungi.
• Antibiotics & Infections > Onychomycosis
Targets both superficial and invasive fungal nail infections. Administered as continuous or pulse therapy, leading to visible nail improvement and high mycological cure rates.
• Antibiotics & Infections > Systemic Fungal Infections
Used in management of severe infections including aspergillosis, cryptococcosis, candidiasis, and paracoccidioidomycosis. Often utilized after amphotericin B induction or as a primary oral option when IV access is not ideal.
• Antibiotics & Infections > Prophylactic Use in Immunocompromised Patients
Employed in patients with hematological malignancies, transplant recipients, and those on immunosuppressive therapies to prevent life-threatening fungal infections.
Key Benefits / Mechanism
Itraconazole binds to fungal cytochrome P450 enzymes, blocking ergosterol biosynthesis, a key structural component of the fungal membrane. This inhibition increases cell permeability, leading to leakage and eventual fungal cell death.
Its high affinity for lipophilic and keratinized tissues ensures extended duration of activity, making it ideal for both dermatologic and systemic applications. Oral bioavailability is enhanced when taken with food, and the formulation allows for predictable tissue distribution.
Itraconazole acts as fungistatic at lower concentrations but may become fungicidal at higher systemic levels. Long-term administration requires hepatic monitoring due to its metabolic profile.
Adults
• Blastomycosis: 200 mg three times daily for 3 days, then 200 mg once daily (Max: 400 mg/day). Severe or CNS cases: 200 mg twice–three times daily for ≥12 months following amphotericin B.
• Histoplasmosis: 200 mg three times daily for 3 days, then 200 mg once–twice daily. Acute pulmonary: 6–12 weeks; Disseminated: ≥12 months; CNS: twice–three times daily ≥12 months or until CSF clearance.
• Aspergillosis: 200 mg three times daily for 3 days, then 200 mg twice daily. Used in ABPA and invasive aspergillosis.
• Oral Thrush: 200 mg once daily for 1–2 weeks; refractory cases: 100 mg twice daily for 2–4 weeks.
• Esophageal Candidiasis: 100–200 mg once daily for ≥3 weeks and 2 weeks after symptom resolution.
• Onychomycosis: Toenails – 200 mg once daily for 12 weeks. Fingernails – 200 mg twice daily for 1 week, pause 3 weeks, repeat × 2 cycles.
• Coccidioidomycosis: 200 mg twice daily; CNS cases may require lifelong therapy.
• Sporotrichosis: Cutaneous – 200 mg once daily for 3–6 months. Disseminated/CNS – 200 mg twice daily for ≥12 months.
• Cryptococcosis (non-CNS): 200 mg twice daily for 6–12 months.
• Cryptococcal Meningitis: 200 mg twice daily for ≥8 weeks (consolidation).
• Vaginal Candidiasis: 200 mg once daily for 3–7 days.
• Microsporidiosis: 400 mg once daily; combine with albendazole in systemic cases.
• Paracoccidioidomycosis: 200 mg once daily for 9–18 months.
Pediatrics
• Blastomycosis: 10 mg/kg once daily for 6–12 months (Max: 400 mg/day). Severe/CNS: same dose ≥12 months after amphotericin B.
• Histoplasmosis: 5–10 mg/kg/day divided twice daily (Max: 400 mg/day). Prophylaxis: 5 mg/kg once daily.
• HIV-infected children: 2–5 mg/kg three times daily × 3 days, then twice daily for 12 months (Max: 200 mg/dose). CNS/post-AmB: same protocol ≥12 months.
• Oral Thrush: 2.5 mg/kg twice daily for 7–14 days (Max: 400 mg/day). Adolescents: 200 mg once daily.
• Esophageal Candidiasis: Children – 2.5 mg/kg twice daily ≥3 weeks. Adolescents – 200 mg once daily for 14–21 days.
• Coccidioidomycosis: Children – 2–5 mg/kg three times daily × 3 days, then twice daily (Max: 200 mg/dose). Adolescents – 200 mg twice–three times daily.
• Cryptococcosis: Children – 5 mg/kg once daily ≥1 year. CNS cases – 2.5–5 mg/kg three times daily × 3 days, then 5–10 mg/kg once daily ≥8 weeks.
• Vaginal Candidiasis: 200 mg once daily for 3–7 days (adolescents).
• Microsporidiosis: 400 mg once daily (adolescents) with albendazole.
• Sporotrichosis: 6–10 mg/kg once daily (Max: 400 mg/day); disseminated cases follow same protocol.
Administration Guidance
Take capsules immediately after a full meal to optimize absorption. Avoid concurrent use with antacids or proton pump inhibitors unless separated by several hours. If a dose is missed, take it promptly unless near the next scheduled dose—do not double. Long-term therapy requires regular liver enzyme monitoring. Use cautiously in patients with ventricular dysfunction or a history of heart failure.
Store below 25°C in a cool, dry place protected from moisture and direct sunlight.
Do not transfer capsules out of their original packaging.
Ensure the cap is tightly closed after use.
Keep away from children and pets.
Common: gastrointestinal upset, headache, dizziness, fatigue, skin rash, and altered taste.
Serious: hepatic dysfunction, congestive heart failure, hypokalemia, and QT prolongation.
Rare but severe: hypersensitivity reactions, SJS/TEN, and hepatocellular injury.
Monitoring: regular liver function tests and ECG monitoring are advised in long-term or high-dose regimens.
Precaution: discontinue and seek immediate medical help if symptoms of liver injury, allergic skin reaction, or cardiac irregularities occur.
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