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| Generic For | SPORANOX |
|---|---|
| Active Ingredient | ITRACONAZOLE |
| Strength | 100MG |
| Manufacturer | CIPLA |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 15 CAPSULES | $ 1.13 | $ 16.90 |
$ 14.36
Apply ZARVY26 (-15%)
You save $ 2.53
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| 2 BOXES - 30 CAPSULES | $ 0.90 |
20% $ 33.80
$ 26.90
|
$ 22.87
Apply ZARVY26 (-15%)
You save $ 4.04
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| ★ Best Value 3 BOXES - 45 CAPSULES | $ 0.82 |
27% $ 50.70
$ 36.90
|
$ 31.37
Apply ZARVY26 (-15%)
You save $ 5.54
|
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Itralase 100 contains itraconazole 100mg, a potent broad-spectrum antifungal from the triazole class. It works by inhibiting the fungal cytochrome P450 enzyme lanosterol 14-α-demethylase, thereby disrupting ergosterol synthesis—an essential component of fungal cell membranes. This mechanism weakens the fungal cell structure and inhibits growth. Itraconazole has excellent tissue penetration, particularly into keratinized tissues like skin and nails, as well as into the lungs and mucosal membranes. It is highly effective against both superficial and systemic mycoses, including Candida, Aspergillus, and Histoplasma infections. Owing to its strong efficacy and safety profile, itraconazole is widely recommended by major clinical guidelines such as those from IDSA and CDC for both treatment and prophylaxis of fungal infections, especially in immunocompromised hosts.
- Antibiotics & Infections > Vaginal & Oral Candidiasis Used for recurrent vulvovaginal candidiasis and oral thrush that are unresponsive to topical treatment. Provides systemic antifungal coverage, easing itching, discharge, white plaques, and inflammation. > Tinea Versicolor & Dermatophytosis Indicated for tinea corporis, cruris, pedis, and versicolor. Offers broader and more consistent efficacy than topical agents, especially in widespread or recalcitrant infections. > Fungal Keratitis Used in combination with topical antifungal eye drops for deep-seated corneal fungal infections. Reduces inflammation, pain, and vision disturbances. > Onychomycosis Effective in treating fungal nail infections, including both fingernails and toenails. Administered via continuous or pulse dosing with high cure rates and good nail bed penetration. > Systemic Fungal Infections Recommended for aspergillosis, cryptococcosis (including meningitis), histoplasmosis, and paracoccidioidomycosis. Offers a valuable alternative or follow-up to amphotericin B in invasive mycoses. > Prophylactic Use in Immunocompromised Patients Used to prevent invasive fungal infections in patients undergoing chemotherapy, stem cell transplantation, organ transplants, or long-term corticosteroid therapy.
Itraconazole’s antifungal activity stems from its inhibition of ergosterol synthesis, essential for maintaining fungal cell membrane integrity and function. This action results in cell membrane destabilization and fungal death. Unlike some azoles, itraconazole exhibits a high lipophilicity, enabling deep tissue and mucosal penetration and prolonged antifungal activity. It accumulates in nails, skin, lungs, and inflamed tissues, making it particularly effective in dermal and systemic infections. It is generally fungistatic but may be fungicidal at higher concentrations. Long-term therapy is feasible with monitoring, especially in chronic infections or immunocompromised individuals. It also exerts minimal impact on human cholesterol synthesis, enhancing safety for extended use.
Adults - Blastomycosis: 200 mg TID × 3 days, then 200 mg QD; max 400 mg/day. Severe CNS cases require IV amphotericin B first, then 200 mg BID–TID × ≥12 months. - Histoplasmosis: 200 mg TID × 3 days, then 200 mg QD–BID. Acute pulmonary: 6–12 weeks; disseminated: ≥12 months; CNS: BID–TID until CSF clearance. - Aspergillosis: 200 mg TID × 3 days, then 200 mg BID. Used as salvage or primary therapy in ABPA or chronic forms. - Oral thrush: 200 mg QD × 1–2 weeks; refractory: 100 mg BID × up to 28 days. - Esophageal candidiasis: 100–200 mg QD ≥3 weeks, continuing 2 weeks after symptom resolution. - Onychomycosis: - Toenails: 200 mg QD × 12 weeks - Fingernails: 200 mg BID × 1 week, repeat after 3-week gap × 2 cycles - Coccidioidomycosis: 200 mg BID for pulmonary and osseous forms; CNS: 200 mg BID–QID for lifetime use. - Sporotrichosis: - Cutaneous: 200 mg QD × total 3–6 months - Severe/disseminated: 200 mg BID × ≥12 months - Cryptococcosis (non-CNS): 200 mg BID × 6–12 months - Cryptococcal meningitis: 200 mg BID × ≥8 weeks (consolidation) - Vaginal candidiasis: 200 mg QD × 3–7 days - Microsporidiosis: 400 mg QD; used with albendazole for disseminated disease - Paracoccidioidomycosis: 200 mg QD × 9–18 months Pediatrics - Blastomycosis: 10 mg/kg QD × 6–12 months (Max 400 mg/day); severe cases post-amphotericin B. - Histoplasmosis: 5–10 mg/kg/day divided BID (Max 400 mg/day); prophylaxis: 5 mg/kg QD. - HIV-infected children: 2–5 mg/kg TID × 3 days → BID × 12 months; CNS: ≥12 months until CSF clearance. - Oral thrush (fluconazole-resistant): 2.5 mg/kg BID × 7–14 days; adolescents: 200 mg QD. - Esophageal candidiasis: 2.5 mg/kg BID ≥3 weeks, continuing 2 weeks post-symptoms. - Coccidioidomycosis: 2–5 mg/kg TID × 3 days → BID; adolescents: 200 mg BID–TID. - Cryptococcosis: 5 mg/kg QD × ≥1 year (Max 200 mg/dose); meningitis loading: 2.5–5 mg/kg TID × 3 days → maintenance 5–10 mg/kg/day × ≥8 weeks. - Vaginal candidiasis: 200 mg QD × 3–7 days (adolescents) - Microsporidiosis: 400 mg QD (adolescents), with albendazole - Sporotrichosis: 6–10 mg/kg QD (Max 400 mg/day); disseminated: same as above Itraconazole capsules should be taken immediately after a full meal to enhance gastrointestinal absorption. Avoid coadministration with proton pump inhibitors or antacids unless spaced several hours apart. If a dose is missed, take it as soon as remembered, but skip if it's close to the next scheduled dose. Do not double the dose. In patients with liver disease or heart failure, use with caution. Regular monitoring of hepatic enzymes and signs of cardiac dysfunction is recommended. Itraconazole is contraindicated in individuals with known ventricular dysfunction or active heart failure.
Store below 25°C in a dry location away from direct light and moisture. Keep capsules in their original blister pack or container until use. Ensure the container is tightly closed after opening. Keep out of reach of children.
Common side effects include nausea, vomiting, headache, abdominal pain, dizziness, rash, and gastrointestinal upset. Serious adverse events include hepatotoxicity, congestive heart failure, peripheral neuropathy, and QT interval prolongation. Rare but severe effects include Stevens-Johnson syndrome and toxic epidermal necrolysis. Liver function tests should be monitored during prolonged use, particularly in high-risk individuals. Discontinue use and consult a physician if signs of jaundice, fatigue, dark urine, leg swelling, or irregular heartbeat appear.
My doctor prescribed Itralase for a stubborn fungal infection, and it has been very effective. So grateful for this reliable pharmacy.
The site is very user-friendly. I found the Itralase I needed and placed my order in under a minute without any hassle.
Ho ordinato Itralase su consiglio del medico. La spedizione in Italia è stata veloce e il prodotto è risultato efficace per la mia infezione.
I needed to start my treatment course right away, and I was so impressed with how quickly my order arrived from this site.
For a prescription like this, you need a source you can trust. This pharmacy is professional, discreet, and reliable.
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