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| Generic For | SPORANOX |
|---|---|
| Active Ingredient | ITRACONAZOLE |
| Strength | 100MG |
| Manufacturer | GLENMARK |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 CAPSULES | $ 0.47 | $ 46.90 |
$ 39.86
Apply ZARVY26 (-15%)
You save $ 7.04
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| 2 BOXES - 200 CAPSULES | $ 0.49 | $ 98.90 |
$ 84.07
Apply ZARVY26 (-15%)
You save $ 14.84
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| ★ Best Value 3 BOXES - 300 CAPSULES | $ 0.50 | $ 148.90 |
$ 126.57
Apply ZARVY26 (-15%)
You save $ 22.34
|
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Syntran 100 contains Itraconazole 100mg, a systemic triazole antifungal agent that disrupts the synthesis of ergosterol, an essential component of fungal cell membranes. By targeting fungal cytochrome P450 enzymes, it weakens cell structure and inhibits fungal growth.
Due to its lipophilic nature and strong keratin affinity, itraconazole accumulates in nails, skin, and mucous membranes, ensuring prolonged antifungal activity even after dosing stops.
It is widely indicated for both superficial infections such as tinea and candidiasis, as well as serious systemic mycoses including aspergillosis, cryptococcosis, and histoplasmosis. With its long half-life and broad-spectrum efficacy, Syntran 100 is also valuable for prophylactic use in immunocompromised patients, helping reduce morbidity from invasive fungal infections.
• Antibiotics & Infections > Vaginal & Oral Candidiasis
Effective for managing recurrent vulvovaginal candidiasis and oral thrush when topical agents are insufficient. Rapidly relieves itching, burning, discharge, and mucosal plaques.
• Antibiotics & Infections > Tinea Versicolor & Dermatophytosis
Treats tinea corporis, cruris, pedis, and versicolor. Offers systemic clearance beyond the reach of topical creams and improves patient adherence due to weekly dosing options.
• Antibiotics & Infections > Fungal Keratitis
Used with topical antifungals to combat fungal infection in the cornea. Improves pain, photophobia, and blurred vision associated with fungal eye disease.
• Antibiotics & Infections > Onychomycosis
Achieves deep nail penetration for durable treatment of fingernail and toenail fungal infections. Can be administered via continuous or pulse therapy with high clinical success rates.
• Antibiotics & Infections > Systemic Fungal Infections
Essential therapy for severe fungal diseases like aspergillosis, candidemia, cryptococcal meningitis, and endemic fungal infections. Often serves as first-line or step-down therapy after amphotericin B.
• Antibiotics & Infections > Prophylactic Use in Immunocompromised Patients
Used preventively in leukemia patients, transplant recipients, and individuals on high-dose corticosteroids to reduce the risk of invasive fungal infections.
Key Benefits / Mechanism
Itraconazole selectively inhibits lanosterol 14-α-demethylase, suppressing the formation of ergosterol and increasing fungal membrane permeability. This disruption interferes with replication and ultimately causes fungal cell death.
Its strong affinity for keratin and lipids ensures long-term tissue presence in skin, nails, and lungs, making it highly effective for both superficial and systemic infections.
Itraconazole is active against yeasts and molds, showing fungistatic or fungicidal activity depending on drug concentration and pathogen type. It is particularly valuable in deep or disseminated mycoses, and offers an oral alternative where intravenous therapy is not ideal.
Although generally well-tolerated, long-term use requires monitoring for potential hepatic and cardiac side effects.
Adults
• Blastomycosis: 200 mg three times daily for 3 days, then 200 mg once daily (Max: 400 mg/day). Severe or CNS cases: 200 mg twice–three times daily for ≥12 months after IV amphotericin B.
• Histoplasmosis: 200 mg three times daily for 3 days, then 200 mg once–twice daily. Acute pulmonary: 6–12 weeks; Disseminated: ≥12 months; CNS: BID–TID until CSF clearance.
• Aspergillosis: 200 mg three times daily for 3 days, then 200 mg twice daily. Suitable as salvage therapy or for ABPA.
• Oral Thrush: 200 mg once daily for 1–2 weeks; refractory cases: 100 mg twice daily for up to 28 days.
• Esophageal Candidiasis: 100–200 mg once daily for ≥3 weeks and at least 2 weeks after symptoms resolve.
• Onychomycosis: Toenails – 200 mg once daily for 12 weeks. Fingernails – 200 mg twice daily for 1 week, pause 3 weeks, repeat × 2 cycles.
• Coccidioidomycosis: 200 mg twice daily for pulmonary/bone disease; BID–QID lifelong in CNS cases.
• Sporotrichosis: Cutaneous – 200 mg once daily for 3–6 months. Disseminated/CNS – 200 mg twice daily for ≥12 months.
• Cryptococcosis (non-CNS): 200 mg twice daily for 6–12 months.
• Cryptococcal Meningitis: 200 mg twice daily for ≥8 weeks (consolidation phase).
• Vaginal Candidiasis: 200 mg once daily for 3–7 days.
• Microsporidiosis: 400 mg once daily; co-administer with albendazole in disseminated forms.
• Paracoccidioidomycosis: 200 mg once daily for 9–18 months.
Pediatrics
• Blastomycosis: 10 mg/kg once daily for 6–12 months (Max: 400 mg/day); severe cases require initial amphotericin B.
• Histoplasmosis: 5–10 mg/kg/day in 2 doses (Max: 400 mg/day); prophylaxis: 5 mg/kg once daily.
• HIV-Positive Children: 2–5 mg/kg three times daily for 3 days, then twice daily for 12 months. CNS/post-AmB: same dosing for ≥12 months. Secondary prophylaxis: 5–10 mg/kg once daily (Max: 200 mg/dose).
• Oral Thrush (fluconazole-resistant): 2.5 mg/kg twice daily for 7–14 days (Max: 400 mg/day). Adolescents: 200 mg once daily.
• Esophageal Candidiasis: Children – 2.5 mg/kg twice daily for ≥3 weeks and 2 weeks beyond symptoms. Adolescents – 200 mg once daily for 14–21 days.
• Coccidioidomycosis: Children – 2–5 mg/kg three times daily for 3 days, then twice daily (Max: 200 mg/dose). Adolescents – 200 mg twice–three times daily.
• Cryptococcosis: Children – 5 mg/kg once daily for ≥1 year. Meningitis – loading 2.5–5 mg/kg three times daily for 3 days, then 5–10 mg/kg/day for ≥8 weeks.
• Vaginal Candidiasis: 200 mg once daily for 3–7 days (adolescents).
• Microsporidiosis: 400 mg once daily (adolescents), co-administered with albendazole.
• Sporotrichosis: 6–10 mg/kg once daily (Max: 400 mg/day); disseminated cases follow same protocol.
Administration Guidance
Take itraconazole capsules immediately after a full meal to maximize absorption. Avoid taking with antacids or proton pump inhibitors unless clinically necessary and appropriately spaced. If a dose is missed, take it promptly unless near the next scheduled dose—do not double. Liver function tests should be performed during prolonged use. Use cautiously in patients with a history of heart failure, arrhythmias, or hepatic impairment.
Store in a cool, dry place at temperatures below 25°C.
Protect from moisture, direct sunlight, and high humidity.
Keep capsules in original packaging until administration.
Ensure container is sealed tightly after use.
Keep out of reach of children.
Common: headache, nausea, vomiting, abdominal pain, dizziness, and skin rash.
Serious: elevated liver enzymes, hepatotoxicity, congestive heart failure, peripheral neuropathy, and QT interval prolongation.
Rare but severe: Stevens-Johnson syndrome and toxic epidermal necrolysis.
Monitoring: routine liver function tests and cardiac evaluation for long-term therapy.
Seek care: immediate medical attention if jaundice, dark urine, leg swelling, or irregular heartbeat occur.
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