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| Generic For | DIFLUCAN |
|---|---|
| Active Ingredient | FLUCONAZOLE |
| Strength | 200MG |
| Manufacturer | KACHHELA MEDEX |
| Pack Size | Price Per Unit | Unit Price | QTY | CART | Best Coupon Price MAX DISCOUNT |
|---|---|---|---|---|---|
| 1 BOX - 100 TABLETS | $ 0.98 | $ 97.90 |
$ 83.22
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You save $ 14.69
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| 2 BOXES - 200 TABLETS | $ 0.90 |
8% $ 195.80
$ 179.90
|
$ 152.92
Apply ZARVY26 (-15%)
You save $ 26.99
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| ★ Best Value 3 BOXES - 300 TABLETS | $ 0.87 |
12% $ 293.70
$ 259.90
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$ 220.92
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You save $ 38.98
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Konaqueen 200 contains Fluconazole 200mg, a potent triazole antifungal that disrupts fungal cell membrane integrity by inhibiting lanosterol 14-α-demethylase, an enzyme critical for ergosterol synthesis. This leads to increased membrane permeability and impaired fungal cell viability.
Fluconazole is highly effective against Candida species, Cryptococcus neoformans, and a range of systemic and mucosal fungal pathogens. With excellent oral bioavailability and broad tissue penetration, it is widely used for fungal infections of the bloodstream, brain, urinary tract, and mucous membranes.
Due to its favorable safety profile and predictable pharmacokinetics, fluconazole is also indicated for long-term prophylaxis in immunocompromised patients, including those undergoing chemotherapy, organ transplantation, or living with HIV/AIDS, where it helps reduce the risk of opportunistic fungal infections.
• Antibiotics & Infections > Vaginal & Oral Candidiasis
Relieves itching, discharge, inflammation, and oral white patches caused by Candida overgrowth. A single oral dose is often effective for uncomplicated vaginal infections.
• Antibiotics & Infections > Esophageal Candidiasis
Improves symptoms such as painful swallowing and burning in the esophagus due to fungal infection. Frequently prescribed following endoscopic confirmation.
• Antibiotics & Infections > Cryptococcal Meningitis
Maintains suppression and prevents relapse of fungal meningitis in immunocompromised individuals, particularly after amphotericin B induction therapy.
• Antibiotics & Infections > Systemic Fungal Infections
Treats invasive candidiasis involving the blood, lungs, urinary tract, or other organs. Oral administration enables effective outpatient management.
• Antibiotics & Infections > Dermatophytosis & Tinea Infections
Effective for athlete’s foot, ringworm, and jock itch with once-weekly dosing. Often preferred over topical antifungals for improved adherence and broader clearance.
• Antibiotics & Infections > Prophylactic Use in Immunocompromised Patients
Used to prevent fungal infections in high-risk groups such as patients undergoing cancer treatment, stem cell therapy, or organ transplantation.
Key Benefits / Mechanism
Fluconazole blocks fungal lanosterol 14-α-demethylase, a critical enzyme in ergosterol biosynthesis. Without ergosterol, fungal cell membranes become unstable, leading to increased permeability, cell lysis, and eventual fungal death.
It demonstrates fungistatic or fungicidal activity depending on the pathogen type and infection site. Fluconazole has a strong selectivity for fungal enzymes over human enzymes, which minimizes systemic toxicity.
The drug achieves effective therapeutic concentrations in the cerebrospinal fluid, bones, kidneys, and eyes, making it suitable for systemic and CNS infections. Long-term therapy is generally well-tolerated, with minimal risk of dependence or cumulative toxicity, supporting its use in prolonged or prophylactic regimens.
Adults
• Vaginal Candidiasis: 150 mg single dose (uncomplicated); 150 mg every 72 hours for 2–3 doses (complicated). Recurrent: 150 mg once weekly for 6 months.
• Oral Thrush: 200 mg on day 1, then 100 mg daily for 7–14 days; severe cases up to 200 mg/day.
• Esophageal Candidiasis: 200 mg on day 1, then 100–400 mg/day for ≥3 weeks.
• Systemic Candidiasis: 800 mg loading dose, then 400 mg/day. Continue for 14 days after negative blood culture.
• Cryptococcal Meningitis: 400 mg on day 1, then 200–800 mg/day. Consolidation: ≥8 weeks; Maintenance: 200 mg/day for 6–12 months or lifelong in AIDS patients.
• Onychomycosis: 150–300 mg weekly for 3–6 months (fingernails) or 6–12 months (toenails).
• Other Deep Infections (e.g., histoplasmosis, blastomycosis): 400–800 mg/day for 6–12 months or longer, depending on response.
Pediatrics
• Oral/Esophageal Candidiasis: ≤2 weeks old – 3 mg/kg every 72 hrs. >2 weeks old – 6 mg/kg on day 1, then 3 mg/kg/day. HIV patients: 6–12 mg/kg/day.
• Systemic Candidiasis: 6–12 mg/kg/day, for ≥14 days after blood culture clearance.
• Cryptococcal Meningitis: 12 mg/kg on day 1, then 6–12 mg/kg/day depending on severity.
• Cardiac/CNS Fungal Infections: 6–12 mg/kg/day; adjust duration based on clinical response.
• Prophylaxis: 6–12 mg/kg/day, tailored to immune status and infection risk.
• Adolescents (Vaginal Candidiasis): 150 mg single dose, or 100–200 mg/day for ≥7 days. For suppression: 150 mg weekly.
Administration Guidance
Fluconazole may be taken with or without food. If a dose is missed, take it promptly unless close to the next scheduled dose; do not double. In renal impairment, dosing interval should be extended according to creatinine clearance.
Store in a dry and cool place below 25°C, away from heat and moisture.
Avoid direct sunlight and humidity.
Ensure packaging is tightly sealed after use.
Keep out of reach of children.
Common: nausea, headache, abdominal pain, dizziness, diarrhea, and rash.
Serious: liver enzyme elevation, QT prolongation, seizures, alopecia, and severe skin reactions such as Stevens-Johnson syndrome.
Seek care: discontinue use and seek medical advice if jaundice, persistent vomiting, chest pain, or confusion occur.
Monitoring: periodic liver function testing is recommended for long-term users.
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