Celdaz 100mg, Dacarbazine Injection, AntiCancer Drugs, Chemotherapy, Online Pharmacy
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Celdaz 100mg Injection

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Generic For DTIC-DOME
Active Ingredient DACARBAZINE
Strength 100MG
Manufacturer CELON LABORATORIES
Celdaz 100mg Injection
Celdaz 100mg Injection
Celdaz 100mg Injection
Celdaz 100mg Injection
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Product Description

Celdaz 100mg Injection is an intravenous formulation containing dacarbazine, a cytotoxic alkylating agent classified as a triazene derivative. It is primarily used in the treatment of metastatic malignant melanoma and advanced Hodgkin’s disease. As a prodrug, dacarbazine is metabolized in the liver to its active compound, which interferes with DNA replication and induces apoptosis in rapidly dividing cancer cells. It is commonly administered in hospital settings as part of combination chemotherapy protocols. This therapy is available through trusted online pharmacy channels for patients requiring specialized oncology medications.

Indications & Uses

  • AntiCancer Drugs > Metastatic Malignant Melanoma and Hodgkin's Disease

    Celdaz is indicated for patients with metastatic melanoma as monotherapy and in combination regimens for relapsed or refractory Hodgkin’s disease. In melanoma, it remains a palliative option for patients not eligible for targeted therapies or immunotherapy. In Hodgkin’s lymphoma, it serves as part of second-line combination chemotherapy when first-line treatments have failed or become intolerable. Its use complements supportive dermatologic or adjunct therapies, including Tretinoin Cream, Isotretinoin, and Acne Treatment in relevant clinical settings.

Benefits & Effectiveness

  • Dacarbazine exerts antineoplastic effects as a DNA alkylating agent after hepatic metabolism, forming MTIC that methylates guanine bases.
  • Inhibits DNA, RNA, and protein synthesis, disrupting tumor cell function and inducing apoptosis.
  • Cell cycle–nonspecific cytotoxicity targets rapidly proliferating cells, effective across multiple malignancies.
  • Can be integrated into broader patient care plans alongside therapies like Glucophage, Invokana, or Wegovy for comorbidity management.

Directions for Use

  • Malignant Melanoma (Adults): 2–4.5 mg/kg IV once daily for 10 days; repeat every 4 weeks OR 250 mg/m² IV once daily for 5 consecutive days; repeat every 3 weeks.

  • Hodgkin’s Disease (Adults): 150 mg/m² IV once daily for 5 days in combination chemotherapy; repeat every 4 weeks OR 375 mg/m² IV on Day 1 in combination chemotherapy; repeat every 15 days.

  • Administer via slow IV infusion to reduce vein irritation and risk of phlebitis.

  • Antiemetic premedication is recommended due to high emetogenic potential.

  • Adjust doses for hepatic or renal impairment and monitor blood counts due to myelosuppression risk.

Storage

Store under refrigeration at 2–8°C (36–46°F). Protect from light. Do not freeze. Reconstituted solutions should be used immediately or stored according to manufacturer stability guidelines. Safely discard any unused portion.

Possible Side Effects

  • Common: severe nausea, vomiting, fatigue, and bone marrow suppression (leukopenia, thrombocytopenia).

  • Serious: hepatotoxicity, renal impairment, and rare but life-threatening veno-occlusive liver disease.

  • Local: injection site irritation or tissue necrosis if extravasation occurs.

  • Monitoring: regular CBC, liver enzymes, and renal function tests are essential throughout treatment.

FAQs

Celdaz is used for the treatment of metastatic malignant melanoma and as second-line therapy for Hodgkin’s disease in combination with other anticancer agents.
It is given by intravenous infusion under medical supervision, typically in cycles of 3 to 4 weeks depending on the treatment plan.
Yes. Dacarbazine is highly emetogenic and can cause significant bone marrow suppression, so close monitoring and supportive care are required.
For melanoma, it may be used as monotherapy. For Hodgkin’s lymphoma, it is part of combination regimens such as ABVD or other salvage therapies.
Patients must be monitored for blood counts, liver function, and signs of infusion-related toxicity. Antiemetics should be given to control nausea.

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